Phase 1 · Illinois
Phase 1 clinical trials in Illinois
69 studies have at least one recruiting site in Illinois. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
69 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 1
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions of ABBV-319 in Adult Participants With Systemic Lupus Erythematosus (SLE), Sjogren's Disease (SjD) and…
AbbVie
- Location
- Orland Park, IL + 4 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2)
Nkarta, Inc.
- Location
- Chicago, IL + 14 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1
A Study of ABBV-295 Subcutaneous Injections to Assess Adverse Events and Pharmacokinetics in Adult Participants With Obesity
AbbVie
- Location
- Grayslake, IL + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
Study of Aritinercept in Patients With Generalized Myasthenia Gravis
Aurinia Pharmaceuticals Inc.
- Location
- Chicago, IL + 9 other US sites
- Eligibility basics
- Ages 18–85
- RecruitingPhase 1/Phase 2
Phase 1/2 Study of MZ-1866, an AAV-9 Gene Therapy Delivered by Intracerebroventricular Injection to Participants With Pitt Hopkins Syndrome
Mahzi Therapeutics
- Location
- Chicago, IL + 2 other US sites
- Eligibility basics
- Ages 2–25
- RecruitingPhase 1/Phase 2
A Phase 1/2 Study of the Safety and Efficacy of MVX-220 in Angelman Syndrome
MavriX Bio, LLC
- Location
- Chicago, IL + 2 other US sites
- Eligibility basics
- Ages 4–50
- RecruitingPhase 1/Phase 2
A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)
Solid Biosciences Inc.
- Location
- Chicago, IL + 11 other US sites
- Eligibility basics
- Ages 0 mo–17 · Men only
- RecruitingPhase 1
A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults
UCB Biopharma SRL
- Location
- Chicago, IL + 29 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis
Sonoma Biotherapeutics, Inc.
- Location
- Chicago, IL + 8 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
Study of BHV-1400 in IgA Nephropathy
Biohaven Therapeutics Ltd.
- Location
- Hinsdale, IL + 13 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
A Phase 1/2 Study of NKX019 in Subjects With Autoimmune Disease (Ntrust-1)
Nkarta, Inc.
- Location
- Chicago, IL + 15 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1
A Study Assessing KB407 for the Treatment of Cystic Fibrosis
Krystal Biotech, Inc.
- Location
- Northfield, IL + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Achilles Tendinopathy Embolization
Joint & Vascular Institute
- Location
- Libertyville, IL
- Eligibility basics
- Ages 25–80
- RecruitingPhase 1/Phase 2
A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire Clinical Trial)
Aspa Therapeutics
- Location
- Chicago, IL + 2 other US sites
- Eligibility basics
- Up to age 2
- RecruitingPhase 1/Phase 2
Study to Assess the Safety, Tolerability, and Preliminary Efficacy of ST266 in Infants With Necrotizing Enterocolitis (NEC)
Noveome Biotherapeutics, formerly Stemnion
- Location
- Evanston, IL + 7 other US sites
- Eligibility basics
- Ages 0 mo–2 mo
- RecruitingPhase 1/Phase 2
Study to Evaluate the Safety and Efficacy of the 10 GE Xenokidney in Patients With ESRD
United Therapeutics
- Location
- Chicago, IL + 1 other US site
- Eligibility basics
- Ages 40–70
- RecruitingPhase 1/Phase 2
Evaluation of ELU42 Topical Spray for the Treatment of Diabetic Foot Ulcers
Eluciderm Inc
- Location
- O'Fallon, IL + 3 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1
Lateral Plantar Artery Embolization For Plantar Fasciitis
Joint & Vascular Institute
- Location
- Libertyville, IL
- Eligibility basics
- Ages 25–80
- RecruitingPhase 1/Phase 2
Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia
ModernaTX, Inc.
- Location
- Chicago, IL + 7 other US sites
- Eligibility basics
- Any age listed
- RecruitingPhase 1/Phase 2
A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)
Neurona Therapeutics
- Location
- Chicago, IL + 15 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
Treatment of Moderate to Severe Refractory Crohn's Disease
Tr1X, Inc.
- Location
- Chicago, IL + 12 other US sites
- Eligibility basics
- Ages 18–65
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.