Mental health · Illinois
Mental health studies in Illinois
71 studies have at least one recruiting site in Illinois. Mental health research includes studies of depression, anxiety, PTSD, bipolar disorder, schizophrenia and ADHD, testing medicines, devices and talk therapies.
71 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteers
J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations
University of Chicago
- Location
- Chicago, IL
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Sleep, Dreaming, and Virtual Reality for Mental Health
Northwestern University
- Location
- Evanston, IL + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Observational Study of Decentralized Urine Optical Interaction Patterns Associated With Environmental Microplastic and Nanoplastic Exposure
Ecotera Health LLC
- Location
- Chicago, IL + 50 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 3
Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia
Reviva Pharmaceuticals
- Location
- Chicago, IL + 16 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 3
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder
Bristol-Myers Squibb
- Location
- Chicago, IL + 18 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2/Phase 3
Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder
COMPASS Pathways
- Location
- Chicago, IL + 8 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
Definium Therapeutics US, Inc.
- Location
- Chicago, IL + 22 other US sites
- Eligibility basics
- Ages 18–74
- Recruiting
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With…
LivaNova
- Location
- Chicago, IL + 49 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 4
A Study to Evaluate the Effect of KarXT on Urological Safety
Bristol-Myers Squibb
- Location
- Chicago, IL + 12 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 4
A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)
Alpha Cognition, Inc
- Location
- Northbrook, IL + 21 other US sites
- Eligibility basics
- Ages 50+
- Recruiting
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Abbott Medical Devices
- Location
- Chicago, IL + 24 other US sites
- Eligibility basics
- Ages 22–70
- RecruitingPhase 3
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Cybin IRL Limited
- Location
- Chicago, IL + 27 other US sites
- Eligibility basics
- Ages 18–85
- RecruitingPhase 3
A Study to Evaluate the Long-term Safety and Tolerability of Xanomeline and Trospium Chloride for the Treatment of Psychiatric Disorders in Children and Adolescents
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
- Location
- Chicago, IL + 12 other US sites
- Eligibility basics
- Ages 5–17
- RecruitingPhase 2
A Long-Term Open-Label Study of ML-007C-MA in Adults With Schizophrenia
MapLight Therapeutics
- Location
- Chicago, IL + 41 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
Draig Therapeutics Ltd
- Location
- Chicago, IL + 19 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 2
ALTO-100 in Bipolar Disorder With Depression (BD-D)
Alto Neuroscience
- Location
- Chicago, IL + 38 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 3
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
Axsome Therapeutics, Inc.
- Location
- Chicago, IL + 35 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2
A Study of Brenipatide in Adult Participants With Schizophrenia
Eli Lilly and Company
- Location
- Chicago, IL + 31 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingPhase 3
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
Eli Lilly and Company
- Location
- Chicago, IL + 28 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 3
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)
Bristol-Myers Squibb
- Location
- Chicago, IL + 12 other US sites
- Eligibility basics
- Ages 13–17
- Recruiting
MaioRegen Prime Study for the Treatment of Deep Osteochondral Lesion of the Knee
Fin-Ceramica Faenza Spa
- Location
- Oak Brook, IL + 7 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingPhase 3
A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
Janssen Research & Development, LLC
- Location
- Chicago, IL + 33 other US sites
- Eligibility basics
- Ages 18–74
- RecruitingPhase 2
Phase 2, Efficacy and Safety Study of ACP-204 in Lewy Body Dementia Psychosis
ACADIA Pharmaceuticals Inc.
- Location
- Chicago, IL + 27 other US sites
- Eligibility basics
- Ages 55–84
- RecruitingPhase 1
A Study of the Feasibility, Safety and Tolerability of Aticaprant as Adjunctive Treatment in Participants With Schizophrenia
Janssen Research & Development, LLC
- Location
- Chicago, IL + 7 other US sites
- Eligibility basics
- Ages 18–55
Who these studies look for
Studies usually require a confirmed diagnosis and stable circumstances, and they monitor safety closely. If you are in crisis, contact a crisis line or emergency services rather than a study.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Will joining affect my current treatment?
Some studies require changes to medicines, which the study team manages; others add to your usual care. Talk to your own clinician before making any change.