Mental health · Illinois
Mental health studies in Illinois
71 studies have at least one recruiting site in Illinois. Mental health research includes studies of depression, anxiety, PTSD, bipolar disorder, schizophrenia and ADHD, testing medicines, devices and talk therapies.
71 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 3
A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine
Bristol-Myers Squibb
- Location
- Chicago, IL + 19 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2
Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder
AbbVie
- Location
- Chicago, IL + 46 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2
A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
AbbVie
- Location
- Chicago, IL + 32 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
atai Therapeutics, Inc.
- Location
- Chicago, IL + 33 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 3
NBI-1117568-SCZ3029: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia
Neurocrine Biosciences
- Location
- Chicago, IL + 20 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 3
Randomized Withdrawal Study in Patients With Schizophrenia
Vanda Pharmaceuticals
- Location
- Chicago, IL + 21 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2
Study of ALTO-101 in Patients With Schizophrenia
Alto Neuroscience
- Location
- Chicago, IL + 12 other US sites
- Eligibility basics
- Ages 21–55
- RecruitingPhase 2
Study of ALTO-300 in MDD
Alto Neuroscience
- Location
- Chicago, IL + 36 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 4
A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
Axsome Therapeutics, Inc.
- Location
- Chicago, IL + 36 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteers
Fathers and Babies (FAB) Research Study
Northwestern University
- Location
- Chicago, IL
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.
Ann & Robert H Lurie Children's Hospital of Chicago
- Location
- Chicago, IL
- Eligibility basics
- Ages 15–20
- RecruitingHealthy volunteers
CommunityRx-Dementia + Peer Navigation (CRxDpeer)
University of Chicago
- Location
- Chicago, IL
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
On Track for Wellness (OTW) Stepped Wedge Cluster Randomized Trial
University of Illinois at Chicago
- Location
- Chicago, IL
- Eligibility basics
- Any age listed
- RecruitingHealthy volunteers
Cognitive Neurocomputational Task Reliability & Clinical Applications Consortium (CNTRACS): Study 1
Washington University School of Medicine
- Location
- Chicago, IL + 4 other US sites
- Eligibility basics
- Ages 18–59
- RecruitingHealthy volunteers
Study of Mental Health and Relationships
University of Illinois at Chicago
- Location
- Chicago, IL
- Eligibility basics
- Ages 9–16
- RecruitingHealthy volunteers
Future Leaders Program: Testing a Youth Leadership, Engagement, and Mindfulness Program
Boston University Charles River Campus
- Location
- Chicago, IL + 2 other US sites
- Eligibility basics
- Ages 14+
- RecruitingHealthy volunteers
Patient Navigators for Children's Community Mental Health Services in High Poverty Urban Communities
University of Illinois at Chicago
- Location
- Chicago, IL
- Eligibility basics
- Up to age 14
- RecruitingHealthy volunteers
Maternal Mindfulness: Depression and Postpartum Pain
University of Illinois at Urbana-Champaign
- Location
- Champaign, IL
- Eligibility basics
- Ages 18–45 · Women only
- RecruitingHealthy volunteers
Our Voices Matter: Intervention for Depression in Youth
Ann & Robert H Lurie Children's Hospital of Chicago
- Location
- Chicago, IL
- Eligibility basics
- Ages 15–20
- RecruitingHealthy volunteers
Test of Target Engagement of Ambiguity Aversion
Northwestern University
- Location
- Chicago, IL
- Eligibility basics
- Ages 25–60
- RecruitingHealthy volunteers
Testing the Effectiveness and Implementation of a Meditation App for Youth in the Legal System
University of Illinois at Chicago
- Location
- Chicago, IL
- Eligibility basics
- Ages 13–20
- RecruitingHealthy volunteers
Web-Based Toolkit to Improve Cancer-Related Emotional Distress and Anxiety in Rural Older Cancer Survivors
Northwestern University
- Location
- Chicago, IL
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Patient Outcome Reporting for Timely Assessments of Life With Post-Traumatic Stress Disorder
University of Chicago
- Location
- Chicago, IL + 1 other US site
- Eligibility basics
- Ages 18+
Who these studies look for
Studies usually require a confirmed diagnosis and stable circumstances, and they monitor safety closely. If you are in crisis, contact a crisis line or emergency services rather than a study.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Will joining affect my current treatment?
Some studies require changes to medicines, which the study team manages; others add to your usual care. Talk to your own clinician before making any change.