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Test of Target Engagement of Ambiguity Aversion

Northwestern University · with National Institute of Mental Health (NIMH) · NCT06962527

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 25–60 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
140
US sites recruiting
1
Study start
July 7, 2025
Record last updated
May 26, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The present work aims to test whether a single session intervention alters ambiguity aversion, both in terms of people's decision making and their brain responses to ambiguous choices.

Being studied: Uncertainty-focused single session intervention; Maintaining a healthy lifestyle single session intervention

Conditions: Intolerance of Uncertainty; Anxiety; Intolerance of Uncertainty; Anxiety; Depression, Anxiety

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Ages 25 to 60
  • Right-handed
  • Ability to read and write English
  • Capacity to provide informed consent
  • Intolerance of uncertainty score ≥ -0.5 standard deviation below the mean (31st percentile)

Exclusion Criteria

  • Personal history of psychosis, mania, or hypomania
  • Personal history of autism spectrum disorder
  • IQ \< 80 as determined by the Wechsler Test of Adult Reading
  • Head injury with greater than 120 seconds loss of consciousness
  • Neurological condition (e.g., epilepsy, Parkinson's, cerebral palsy, history of stroke)
  • Currently pregnant
  • Use of any implanted electrical device (e.g., pacemaker, spinal stimulator, vagal nerve stimulator, Inspire sleep apnea device, etc.).

Recruiting US locations

  • Northwestern University

    Chicago, IL 60611

    Site contact: Brent I Rappaport, Ph.D. · (312) 585-6603‬ · decisionmaking@northwestern.edu

Study contacts (from the official record)

  • Brent I Rappaport, Ph.D. · (312) 585-6603 · decisionmaking@northwestern.edu
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Test of Target Engagement of Ambiguity Aversion (NCT06962527) | Bored Studies