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RecruitingPhase 3

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

Definium Therapeutics US, Inc. · NCT07592689

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–74 · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 3
Target enrollment
165
US sites recruiting
23
Study start
May 10, 2026
Record last updated
October 23, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Ascend

Being studied: Placebo; DT120

Conditions: Major Depressive Disorder

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Diagnosis of MDD per DSM-5
  • Male or female aged 18 to 74
  • Currently experiencing a major depressive episode (MDE) of ≥8 weeks and ≤24 months duration
  • MADRS Total Score ≥26
  • CGI-S Score ≥4

Exclusion Criteria

  • Certain psychiatric disorders (other than major depressive disorder)
  • First degree relative with or lifetime history of a psychotic disorder or bipolar disorder
  • Current diagnosis of alcohol or substance use disorder (excluding nicotine and caffeine
  • Any clinically significant unstable illness

Recruiting US locations

  • Preferred Research Partners, Inc.

    Little Rock, AR 72211

    Site contact: Stacy Tierney · 501-553-9987 · stierney@preferredresearchpartners.com

  • ATP Clinical Research Orange County

    Orange, CA 92866

    Site contact: Raissa Rebollar · 949-354-5353 · raissar@pnsoc.com

  • Kadima Neuropsychiatry Institute

    San Diego, CA 92037

    Site contact: Alexiss Rivas · 858-412-4130 · alexissr@kadimanp.com

  • Psychedelic Science Institute

    Santa Monica, CA 90404

    Site contact: Ashley Ramos · 310-378-0303 · trialadmin@psychedelicsci.com

  • Mountain View Clinical Research, Inc

    Denver, CO 80209

    Site contact: Jessica Bryant · 720-941-8894 · jessica@mtnresearch.com

  • Clinical Neuroscience Solutions, LLC (Jacksonville)

    Jacksonville, FL 32256

    Site contact: Susan Angel · 904-218-5757 · sangel@cnshealthcare.com

  • K2 Medical Research (Maitland)

    Maitland, FL 32751

    Site contact: Vanessa Carrillo · 407-676-5252 · vanessa.carrillo@k2med.com

  • Clinical Neuroscience Solutions, LLC (Orlando)

    Orlando, FL 32801

    Site contact: Chanel Adams · 407-425-5100 · cadams@cnshealthcare.com

  • K2 Medical Research (Tampa)

    Tampa, FL 33607

    Site contact: Karina Perez · 813-800-5252 · karina.perez@k2med.com

  • CenExel - Atlanta Center for Medical Research

    Atlanta, GA 30331

    Site contact: Denniel Brown · 404-881-5800 · d.brown@cenexel.com

  • CenExel - iResearch Atlanta

    Decatur, GA 30030

    Site contact: Branden Freeman · 404-537-1281 · b.freeman@cenexel.com

  • CenExel - iResearch Savannah

    Savannah, GA 31405

    Site contact: Katie McCants · 912-744-0800 · k.mccants@cenexel.com

  • Uptown Research Institute

    Chicago, IL 60640

    Site contact: Chloe Rzeppa · 773-989-8313 · crzeppa@uptownresearch.com

  • Adams Clinical Watertown

    Boston, MA 02472

    Site contact: Harrison Gillman · 617-744-8542 · hgillman@adamsclinical.com

  • Vitalix Clinical

    Worcester, MA 01608

    Site contact: Rajvi Patel · 413-363-5206 · rpatel@vitalixclinical.com

  • Arch Clinical Trials, LLC

    St Louis, MO 63141

    Site contact: Erica Ehrhardt · 314-282-3521 · eehrhardt@archclinicaltrials.com

  • Redbird Research

    Las Vegas, NV 89119

    Site contact: Pam Pioquinto · 702-577-2000 · pamela@redbird-research.com

  • Adams Clinical Philadelphia

    Philadelphia, PA 19104

    Site contact: Elizabeth Huang · 267-207-2511 · ehuang@adamsclinical.com

  • Coastal Carolina Research

    North Charleston, SC 29405

    Site contact: Brandy Dreyer · 843-856-3784 · brandy.dreyer@coastalcarolinaresearch.com

  • Austin Clinical Trial Partners

    Austin, TX 78737

    Site contact: Cara Fonken · 512-521-0595 · cfonken@austinCTP.com

  • Cedar Clinical Research

    Draper, UT 84020

    Site contact: Kye Cutrubus · 801-369-4219 · kye.cutrubus@numinusnetwork.com

  • Inner Space Research

    Orem, UT 84058

    Site contact: Yohan Paitrault · 801-871-5516 · yohan@innerspaceresearch.com

  • Memory Clinic Inc.

    Bennington, VT 05201

    Site contact: Cynthia Murphy, PhD · 413-281-0576 · research@memorydoc.org

Study contacts (from the official record)

  • Definium Therapeutics Clinical Trials Info Requests · 1-332-282-0479 · clinicaltrials@definiumtx.com
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A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend) (NCT07592689) | Bored Studies