Skip to content
Bored Studies
RecruitingPhase 3

Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

Axsome Therapeutics, Inc. · NCT07484217

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 3
Target enrollment
508
US sites recruiting
40
Study start
February 23, 2026
Record last updated
October 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

CLARITY (Clinical Assessment of Response in the Treatment of Depression with Daytime Sleepiness Using Solriamfetol) is a Phase 3, double-blind, placebo-controlled, multicenter randomized withdrawal trial in patients with major depressive disorder (MDD) with excessive daytime sleepiness (EDS) symptoms consisting of an open-label solriamfetol treatment period and a randomized, double-blind treatment period.

Being studied: Solriamfetol 150 MG; Placebo

Conditions: Major Depressive Disorder With Excessive Daytime Sleepiness Symptoms

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Currently meets the DSM-5 criteria for MDD without psychotic features, based on the SCID-5-CT
  • Excessive daytime sleepiness symptoms
  • Able to comply with study procedures
  • Male or female, aged 18 to 65 years inclusive

Exclusion Criteria

  • Any clinically significant medical (e.g., OSA, narcolepsy), behavioral, or psychiatric disorder, other than MDD with EDS symptoms
  • Unable to comply with study procedures
  • Medically inappropriate for study participation in the opinion of the investigator

Recruiting US locations

Study contacts (from the official record)

  • Study Director · 2123325061 · sol-mdd-302@axsome.com
All sleep studies in Arizona →
Clinical Assessment of Response in the Treatment of Depression… (NCT07484217) | Bored Studies