Phase 1 · St. Louis area, MO
Phase 1 clinical trials in St. Louis area, MO
35 recruiting studies have a site in the St. Louis area. This page includes nearby cities such as Saint Louis, Chesterfield, Creve Coeur, Florissant.
35 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
A Clinical Study of Novel Pneumococcal Vaccine V118C in Children (V118C-002)
Merck Sharp & Dohme LLC
- Location
- St Louis, MO + 14 other US sites
- Eligibility basics
- Ages 2 mo–1
- RecruitingHealthy volunteersPhase 1
A Clinical Trial Investigating the Safety and Biological Activity of the Antibody BNT351 in Adults Living Without and With HIV
BioNTech SE
- Location
- St Louis, MO + 3 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B or Factor VII…
Equilibra Bioscience LLC
- Location
- St Louis, MO + 6 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- St Louis, MO + 4 other US sites
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersEarly Phase 1
PET Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With 64Cu-NODAGA-CANF (Volunteer - Dosimetry Study)
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Light Therapy for Obsessive-compulsive Disorder (OCD)
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 17–35
- RecruitingHealthy volunteersEarly Phase 1
PET Imaging CCR2 in Lung Inflammation
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersPhase 1
NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503
University of Pennsylvania
- Location
- St Louis, MO + 2 other US sites
- Eligibility basics
- Ages 40–85
- RecruitingHealthy volunteersEarly Phase 1
PET Imaging of MMP Activation in AAA: Clinical Component
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
PET Detection of CCR2 in Human Atherosclerosis
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 18–89
- RecruitingPhase 1
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
CRISPR Therapeutics
- Location
- St Louis, MO + 7 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
PBGENE-DMD Phase 1/2a Safety and Preliminary Efficacy Study in Duchenne Muscular Dystrophy (FUNCTION-DMD)
Precision BioSciences, Inc.
- Location
- St Louis, MO + 1 other US site
- Eligibility basics
- Ages 2–7 · Men only
- RecruitingPhase 1/Phase 2
A Study to Learn About the Safety of BIIB147 and Its Effects in Adults With Amyotrophic Lateral Sclerosis (ALS)
Biogen
- Location
- St Louis, MO + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Phase 1 Study of LY5830966 in Participants With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I…
Ajax Therapeutics, Inc., a wholly owned subsidiary of Eli Lilly and Company
- Location
- St Louis, MO + 12 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
Sumitomo Pharma America, Inc.
- Location
- St Louis, MO + 29 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis
Tr1X, Inc.
- Location
- St Louis, MO + 7 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
A Gene Transfer Therapy Study to Evaluate the Safety of and Expression From Delandistrogene Moxeparvovec (SRP-9001) in Participants With Duchenne Muscular Dystrophy (DMD) - Non-Ambulatory Cohort
Sarepta Therapeutics, Inc.
- Location
- St Louis, MO + 10 other US sites
- Eligibility basics
- Ages 2+ · Men only
- RecruitingPhase 1/Phase 2
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
COUR Pharmaceutical Development Company, Inc.
- Location
- Kansas City, MO + 44 other US sites
- Eligibility basics
- Ages 12–35
- RecruitingPhase 1/Phase 2
A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE
AstraZeneca
- Location
- St Louis, MO + 8 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
An Open-label Study of AZD0120 in Adults With Multiple Sclerosis
AstraZeneca
- Location
- St Louis, MO + 4 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingPhase 1
A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of DNL952 in Adult Participants With Late-Onset Pompe Disease
Denali Therapeutics Inc.
- Location
- St Louis, MO + 3 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1
A Study of Amicidin-β Topical Solution for Patients With Surgical or Traumatic Wound Infections
Macro Biologics, Inc.
- Location
- St Louis, MO + 4 other US sites
- Eligibility basics
- Ages 18–79
- RecruitingPhase 1/Phase 2
Descartes-08 for Children, Adolescents, and Young Adults With Autoimmune Disorders
Cartesian Therapeutics
- Location
- St Louis, MO + 2 other US sites
- Eligibility basics
- Ages 12+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.