Phase 1 · Minnesota
Phase 1 clinical trials in Minnesota
61 studies have at least one recruiting site in Minnesota. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
61 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 1/Phase 2
ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)
Ionis Pharmaceuticals, Inc.
- Location
- Saint Paul, MN + 7 other US sites
- Eligibility basics
- Ages 2–65 · Men only
- RecruitingPhase 1/Phase 2
RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus
Cabaletta Bio
- Location
- Minneapolis, MN + 17 other US sites
- Eligibility basics
- Ages 12–65
- RecruitingPhase 1/Phase 2
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
Sumitomo Pharma America, Inc.
- Location
- Minneapolis, MN + 29 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy
Rocket Pharmaceuticals Inc.
- Location
- Rochester, MN + 2 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
A Study of AAVB-039 in Participants With Stargardt Disease (STGD1)
AAVantgarde Bio Srl
- Location
- Rochester, MN + 7 other US sites
- Eligibility basics
- Ages 8–55
- RecruitingPhase 1
NEXUS Study: A Study to Test Single and Multiple Doses of MER511 Given to Adults With Graves' Disease
Merida Biosciences
- Location
- Rochester, MN + 10 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
A Study to Learn About the Study Medicine Called Zavegepant (PF-07930207) in Children With a History of Migraine
Pfizer
- Location
- Minneapolis, MN + 10 other US sites
- Eligibility basics
- Ages 6–11
- RecruitingPhase 1/Phase 2
Safety, PK/PD, and Exploratory Efficacy Study of AMT-191 in Classic Fabry Disease
UniQure Biopharma B.V.
- Location
- Minneapolis, MN + 9 other US sites
- Eligibility basics
- Ages 18–65 · Men only
- RecruitingPhase 1
A Study of SGT-501 Gene Therapy in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
Solid Biosciences Inc.
- Location
- Rochester, MN + 2 other US sites
- Eligibility basics
- Ages 7+
- RecruitingPhase 1/Phase 2
A Study of TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD)
Tessera Therapeutics, Inc.
- Location
- Rochester, MN + 4 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis
Tr1X, Inc.
- Location
- Rochester, MN + 7 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
Dose Escalation Study With Bispecific Antibodies in Adult Participants With Lupus Nephritis
Regeneron Pharmaceuticals
- Location
- Rochester, MN + 2 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingPhase 1/Phase 2
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
COUR Pharmaceutical Development Company, Inc.
- Location
- Minneapolis, MN + 44 other US sites
- Eligibility basics
- Ages 12–35
- RecruitingPhase 1
Safety and Feasibility Study of the CELLSPAN Esophageal Implant (CEI) in Patients Requiring Short Segment Esophageal Replacement
Harvard Apparatus Regenerative Technology, Inc.
- Location
- Rochester, MN + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
ASCEND: Safety and Tolerability of ION337 for the Treatment of Dravet Syndrome
Ionis Pharmaceuticals, Inc.
- Location
- Rochester, MN + 4 other US sites
- Eligibility basics
- Ages 2–12
- RecruitingPhase 1/Phase 2
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne
Sanofi Pasteur, a Sanofi Company
- Location
- Minneapolis, MN + 78 other US sites
- Eligibility basics
- Ages 18–45
- RecruitingPhase 1/Phase 2
AAV Gene Therapy Clinical Study in Adult Classic PKU (PHEdom)
NGGT INC.
- Location
- Minneapolis, MN + 4 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingPhase 1
Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Limbal Stem Cell Deficiency
Claris Biotherapeutics, Inc.
- Location
- Minnetonka, MN + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2)
Nkarta, Inc.
- Location
- Minneapolis, MN + 14 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
A Study With NVC-001 in Patients With LMNA-related Dilated Cardiomyopathy (SUNBEAM-LMNA)
Nuevocor Pte. Ltd.
- Location
- Rochester, MN + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
ISP-001: Sleeping Beauty Transposon-Engineered B Cells for MPS I
Immusoft of CA, Inc.
- Location
- Minneapolis, MN + 1 other US site
- Eligibility basics
- Ages 10+
- RecruitingPhase 1/Phase 2
A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.
Alexion Pharmaceuticals, Inc.
- Location
- Rochester, MN + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingEarly Phase 1
VTP-1000 in Adults With Celiac Disease
Barinthus Biotherapeutics
- Location
- Rochester, MN + 15 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
R-3750 in Patients With Mild to Moderate Ulcerative Colitis
Rise Therapeutics LLC
- Location
- Rochester, MN + 4 other US sites
- Eligibility basics
- Ages 18–65
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.