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RecruitingAccepts healthy volunteersEarly Phase 1

Ketamine and Propofol NeuroImaging

Keith M Vogt · with National Institute of General Medical Sciences (NIGMS) · NCT07294092

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–59 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
60
US sites recruiting
1
Study start
April 10, 2026
Record last updated
May 19, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This is a multi-visit which will collect MRI (pictures of the brain) and EEG (brain waves) data to determine changes in brain connectivity and brain activity for memory formation and pain perception while receiving the commonly-used anesthetic agents ketamine and propofol, both alone and in combination.

Being studied: Propofol; Ketamine; Peripheral Nerve Stimulation

Conditions: Anesthesia; Pain

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adults 18-59 years of age, who:
  • have none of the specific exclusion criteria
  • have a valid email address and valid phone number throughout the study
  • free from any non-MRI compatible implants

Exclusion Criteria

  • are pregnant or attempting to conceive
  • body mass index (BMI) > 35
  • significant memory impairment or hearing loss
  • sleep apnea
  • chronic pain or frequently taking pain medication
  • chronic medical conditions requiring treatment (hypertension, diabetes, high cholesterol)
  • neurologic disease, including seizures and tremor
  • psychiatric diagnoses, including anxiety, depression, panic, or PTSD
  • a history of any of these medical conditions: abnormal heartbeats (cardiac conduction abnormality or arrhythmia), liver or kidney disease, or significant lung disease
  • severe claustrophobia or intolerance of an MRI
  • have metal implants or non-removable metal piercings
  • having a history of adverse reaction to ketamine or propofol
  • daily alcohol or heavy alcohol use; history of alcohol abuse
  • current daily smoker
  • regular or recent marijuana use (including prescribed/medical marijuana)
  • illicit drug use, i.e., street drugs
  • regularly taking: antiepileptics, antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, or sleep-aids

Recruiting US locations

  • University of Pittsburgh

    Pittsburgh, PA 15213

    Site contact: Keith M Vogt, MD, PhD · 4126473147 · kev18@pitt.edu

Study contacts (from the official record)

  • Keith M Vogt, MD, PhD · 4126473147 · kev18@pitt.edu
All healthy volunteers studies in Pennsylvania →
Ketamine and Propofol NeuroImaging (NCT07294092) | Bored Studies