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Ketone Conferred Resiliency Against Sleep Restriction With Nutritional Intervention.

Ohio State University · NCT06075914

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–40 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
60
US sites recruiting
1
Study start
May 1, 2023
Record last updated
June 24, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Sleep deprivation is a major problem in military populations. Some major consequences of sleep loss are inability to concentrate, poor work efficiency, and increase in errors during daily tasks. Ketogenic supplementation is speculated to alleviate some sleep deprivation issues via action of ketones. Ketones are small molecules that appear in the blood when following a ketogenic diet or consuming ketone supplements. The goal of this project is to find out if diet and/or ketones can improve sleep deprivation detriments over 5 days of sleep restriction (-50% from habitual sleep).

Being studied: Ketogenic Intervention; Mediterranean Intervention; Placebo; Ketone Ester

Conditions: Sleep Deprivation; Nutritional Intervention

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Healthy, 18-40 years old.
  • BMI: 20-35 kg/m2
  • Sleep at least 7h per night.
  • Willing to participate in \~9-weeks of testing and provided food.
  • Willing to adhere to all study procedures.

Exclusion Criteria

  • \<18 or >40 years of age
  • >35 body mass index (BMI).
  • Diagnosed sleeping disorders (i.e., sleep apnea, insomnia).
  • Gastrointestinal disorders or food allergies that would interfere with consuming the study supplements.
  • Drink alcohol in excess of 3 drinks/day or 14 drinks/week
  • Have any conditions or contraindications to blood draws.
  • Have been diagnosed with diabetes, liver, kidney, or other metabolic or endocrine dysfunction, or use diabetic medications other than metformin
  • Currently consume a low carbohydrate or ketogenic diet or have done so in the last 3 months
  • Have experienced weight loss of >10% of your body weight within the last 6 months
  • Are pregnant, lactating, or planning on becoming pregnant during the study
  • Have any major psychiatric disorders (e.g., schizophrenia, bipolar disorder)

Recruiting US locations

  • The Ohio State University

    Columbus, OH 43210

    Site contact: Jeff S Volek, PhD · 614-688-1701 · volek.1@osu.edu

Study contacts (from the official record)

  • Jeff S Volek, PhD, RD · 6146881701 · volek.1@osu.edu
  • Madison L Kackley, PhD · 7408171622 · kackley.19@osu.edu
All sleep studies in Ohio →
Ketone Conferred Resiliency Against Sleep Restriction With… (NCT06075914) | Bored Studies