Knee Osteoarthritis Rehabilitation Through Rotational Inertia
University of Colorado, Denver · with NIH/NCATS Colorado CTSA Grant Number T32TR004367 · NCT07424352
Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.
Key facts
- Compensation
- Not posted. Ask the study team before screening.
- Who can join
- Ages 40–70 · All sexes
- Healthy volunteers
- Accepted
- Study type
- Interventional · Not applicable
- Target enrollment
- 60
- US sites recruiting
- 1
- Study start
- August 20, 2025
- Record last updated
- February 20, 2026
Status re-checked against ClinicalTrials.gov within the last 12 hours.
What the study is about
This study is testing whether a new type of exercise program, called eccentric overload training using a flywheel device, can improve stair-climbing ability in people with knee osteoarthritis. The flywheel device provides resistance throughout the entire movement and gives extra challenge during the muscle-lengthening phase of exercise. This type of training may improve muscle structure, strength, and coordination more effectively than conventional methods.
The study's central idea is that better muscle quality and improved coordination will lead to smoother, safer stair movement and reduce the risk of falls. Advanced tools such as ultrasound imaging and motion analysis will be used to measure muscle health and movement patterns in detail.
The hypothesis is that individuals with knee osteoarthritis have poorer muscle quality and less coordinated stair-stepping compared to healthy adults, and that performing eccentric overload training will enhance muscle quality, improve movement coordination, and make stair navigation safer and more efficient.
Being studied: Eccentric resistance training
Conditions: Knee Arthritis, Osteoarthritis
Eligibility criteria
Copied from the official record. The study team makes the final decision at screening.
Show full criteria
Inclusion Criteria Osteoarthritis (OA) Group:
- Aged 40-70 years
- Radiographically confirmed knee OA (Kellgren-Lawrence [KL] Grade 2 or 3)
- Able to walk independently (assistive devices permitted)
Inclusion Criteria Healthy Control Group
- Aged 40-70 years
- No radiographic evidence of knee OA (KL Grade 0 or 1)
- No frequent knee pain
- No history of:
- Knee surgery (e.g., ACL reconstruction, meniscectomy, patellar realignment)
- Significant knee injury (e.g., ligament tears, fractures, dislocations)
- Diagnosed knee conditions (e.g., patellofemoral pain syndrome, bursitis)
Exclusion Criteria
- Uncontrolled hypertension or other cardiovascular disease
- A musculoskeletal condition preventing physical testing
- Neurological muscle weakness (e.g., stroke, spinal cord injury)
- BMI >34.9 kg/m²
- Recent hospitalization (past 3 months)
Recruiting US locations
University of Colorado, Denver
Aurora, CO 80045
Site contact: Katie Boncella · 720-724-1786 · katie.boncella@cuanschutz.edu
Study contacts (from the official record)
- Katie Boncella, MS · 7207241786 · katie.boncella@cuanschutz.edu
- Michael Harris-Love, PT, MPT, DSc, FGSA, FAPTA · 303-724-0687 · michael.harris-love@cuanschutz.edu
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