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RecruitingPhase 2

A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)

Merck Sharp & Dohme LLC · NCT07133633

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–80 · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 2
Target enrollment
315
US sites recruiting
36
Study start
September 26, 2025
Record last updated
October 23, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Researchers are looking for new ways to treat radiographic axial spondyloarthritis (r-axSpA). R-axSpA is a type of arthritis that causes pain, stiffness, and inflammation (swelling) in the spine and joints in the pelvis (hip bone). Radiographic means the damage it causes can be seen on X-rays.

This study will help find out if a study medicine called tulisokibart can treat symptoms of r-axSpA. Researchers will look at different doses of tulisokibart.

Researchers want to know if at least one of the study doses of tulisokibart works better than a placebo to improve r-axSpA symptoms. A placebo looks like the study medicine but has no study medicine in it. Using a placebo helps researchers better understand the effects of the study medicine.

Being studied: Tulisokibart; Placebo

Conditions: Radiographic Axial Spondyloarthritis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

The main inclusion criteria include but are not limited to the following:

  • Has a clinical diagnosis of axial spondyloarthritis (axSpA) and meets the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axSpA including ≥3 months of back pain with age at symptom onset \<45 years
  • Meets the radiographic criterion of the modified New York criteria for ankylosing spondylitis (AS) as determined by central reading at Screening
  • Has active disease at Screening and Randomization
  • Has a history of inadequate response (IR)/intolerance to nonsteroidal anti-inflammatory drugs (NSAIDs) and is biologic disease-modifying antirheumatic drug (bDMARD)-naive, or has a history of IR/intolerance to up to a maximum of 2 bDMARD classes

Exclusion Criteria

The main exclusion criteria include but are not limited to the following:

  • Has any arthritis with onset before age 17 years or current diagnosis of inflammatory joint disease other than radiographic axial spondyloarthritis (r-axSpA) (such as, but not limited to, rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis (PsA), systemic sclerosis, myositis, etc.), or any other conditions that may, in the judgment of the investigator, interfere with the assessment of r-axSpA
  • Has a history of cancer (except fully treated non-melanoma skin cancers or cervical carcinoma in situ after complete surgical removal) within the last 5 years
  • Has any active infection
  • Has known allergies, hypersensitivity, or intolerance to tulisokibart or its excipients

Recruiting US locations

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Chandler ( Site 0036)

    Chandler, AZ 85225

    Site contact: Study Coordinator · 480-443-8400

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Flagstaff ( Site 0021)

    Flagstaff, AZ 86001

    Site contact: Study Coordinator · 480-443-8400

  • Arizona Arthritis & Rheumatology Associates, P.C. - Gilbert ( Site 0022)

    Gilbert, AZ 85297

    Site contact: Study Coordinator · 480-443-8400

  • AARA Arizona Arthritis & Rheumatology Associates, P.C. - Glendale ( Site 0056)

    Glendale, AZ 85306

    Site contact: Study Coordinator · 480-443-8400

  • Arizona Arthritis & Rheumatology Associates, P.C. - Tucson ( Site 0025)

    Tucson, AZ 85704-1140

    Site contact: Study Coordinator · 480-443-8400

  • Providence Medical Foundation ( Site 0049)

    Fullerton, CA 92835

    Site contact: Study Coordinator · 714-626-8610

  • Newport Huntington Medical Group ( Site 0005)

    Huntington Beach, CA 92648

    Site contact: Study Coordinator · 714-378-2440

  • Cohen Medical Centers ( Site 0034)

    Thousand Oaks, CA 91360-3967

    Site contact: Study Coordinator · 713-487-8680

  • Inland Rheumatology Clinical Trials, Inc. ( Site 0002)

    Upland, CA 91786

    Site contact: Study Coordinator · 909-296-8700

  • Denver Arthritis Clinic ( Site 0064)

    Denver, CO 80230

    Site contact: Study Coordinator · 303-394-2828

  • Arthritis and Rheumatic Disease Specialties ( Site 0016)

    Aventura, FL 33180

    Site contact: Study Coordinator · 305-932-4295

  • Bay Area Arthritis and Osteoporosis ( Site 0041)

    Brandon, FL 33511

    Site contact: Study Coordinator · 813-651-4441 Ext 243

  • GNP Research - Hollywood ( Site 0020)

    Cooper City, FL 33024

    Site contact: Study Coordinator · 754-248-3589

  • Innovation Medical Research Center ( Site 0012)

    Palmetto Bay, FL 33157

    Site contact: Study Coordinator · 305-300-2695

  • Chicago Arthritis & Regenerative Medicine ( Site 0042)

    Chicago, IL 60661

    Site contact: Study Coordinator · 480-443-8400

  • Willow Rheumatology and Wellness, PLLC ( Site 0035)

    Willowbrook, IL 60527

    Site contact: Study Coordinator · 630-537-1313

  • John Hopkins University ( Site 0052)

    Baltimore, MD 21224

    Site contact: Study Coordinator · 410-550-0579

  • Arthritis and Rheumatism Associates - Rockville ( Site 0019)

    Rockville, MD 20850

    Site contact: Study Coordinator · 301-942-7600

  • Kansas City Physician Partners ( Site 0027)

    Kansas City, MO 64111

    Site contact: Study Coordinator · 816-384-2827

  • Velocity Clinical Research - West County Rheumatology, St. Louis ( Site 0038)

    St Louis, MO 63131

    Site contact: Study Coordinator · 314-987-2980

  • Logan Health Rheumatology ( Site 0015)

    Kalispell, MT 59901

    Site contact: Study Coordinator · 406-752-2010

  • Physician Research Collaboration, LLC ( Site 0057)

    Lincoln, NE 68516-5497

    Site contact: Study Coordinator · 402-420-3442

  • Inspire Santa Fe Medical Group ( Site 0011)

    Santa Fe, NM 87505

    Site contact: Study Coordinator · 505-490-5984

  • Oregon Health & Science University ( Site 0059)

    Portland, OR 97239

    Site contact: Study Coordinator · 503-494-8637

  • Altoona Center for Clinical Research ( Site 0004)

    Duncansville, PA 16635

    Site contact: Study Coordinator · 814-693-0300

  • Perelman Center for Advanced Medicine ( Site 0060)

    Philadelphia, PA 19104

    Site contact: Study Coordinator · 215-662-2454

  • AARA Clinical Research - Murfreesboro Medical Clinic ( Site 0029)

    Murfreesboro, TN 37128

    Site contact: Study Coordinator · 615-236-2504

  • Rheumatology Associates ( Site 0055)

    Arlington, TX 76012

    Site contact: Study Coordinator · 214-540-0700

  • Arthritis Care of Texas ( Site 0048)

    Corpus Christi, TX 78415

    Site contact: Study Coordinator · 361-400-7700

  • Lone Star Arthritis & Rheumatology Associates, P.C. ( Site 0028)

    Fort Worth, TX 76109

    Site contact: Study Coordinator · 301-942-7600

  • Provecta Research Network LLC ( Site 0054)

    Houston, TX 77027

    Site contact: Study Coordinator · 346-735-8990

  • The University of Texas Health Science Center at Houston ( Site 0065)

    Houston, TX 77030

    Site contact: Study Coordinator · 713-500-6597

  • AARA Clinical Research - Lone Star Arthritis and Rheumatology Associates - Irving ( Site 0032)

    Irving, TX 75039

    Site contact: Study Coordinator · 301-942-7600

  • Epic Medical Research ( Site 0061)

    Red Oak, TX 75154

    Site contact: Study Coordinator · 972-777-6956

  • Advanced Rheumatology of Houston ( Site 0001)

    The Woodlands, TX 77382

    Site contact: Study Coordinator · 936-681-4882

  • DM Clinical Research - TRA ( Site 0010)

    Tomball, TX 77375

    Site contact: Study Coordinator · 346-550-9559

Study contacts (from the official record)

  • Toll Free Number · 1-888-577-8839 · Trialsites@msd.com
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A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic… (NCT07133633) | Bored Studies