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RecruitingPhase 3

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines

Takeda · NCT06671483

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 3
Target enrollment
1088
US sites recruiting
48
Study start
March 3, 2025
Record last updated
October 14, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects the joints and skin in people who have psoriasis (PsO).

The main aim of the study is to know how well zasocitinib (TAK-279) works in participants with active PsA who have not previously been treated with biologic disease-modifying antirheumatic drugs.

The participants will be treated with either zasocitinib, active comparator, or placebo. Participants will be in the study for up to 60 weeks.

Being studied: Zasocitinib; Active Comparator; Placebo

Conditions: Psoriatic Arthritis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Age

  • The participant is aged 18 years or older at the time of signing the informed consent form (ICF). In South Korea, the age requirement for adult participants is >=19 years of age.

Disease Characteristics

  • The participant has a diagnosis of PsA.
  • The participant must have signs and symptoms of PsA for at least 3 months prior to screening.
  • The participant meets the Classification Criteria for Psoriatic Arthritis (CASPAR criteria).
  • The participant has active arthritis as shown by a minimum of >=3 tender joints in TJC68 and >=3 swollen joints in SJC66 at the screening and baseline (Day 1) visits.
  • The participant has at least 1 active lesion of plaque PsO >=2 cm in diameter, or any nail or nail bed changes characteristic of PsO.

Medications for PsA

  • The participant has had at least one of the following:
  • Inadequate response to a nonsteroidal anti-inflammatory drug (NSAID) (not applicable in the European Union [EU]/ European Economic Area [EEA]), OR
  • Inadequate response to a conventional synthetic disease-modifying antirheumatic drug (csDMARD).

Exclusion Criteria

PsA and PsO

  • The participant has other disease(s) that might confound the evaluations of benefit of zasocitinib therapy, including but not limited to rheumatoid arthritis, axial spondyloarthritis, systemic lupus erythematosus, Lyme disease, gout, or fibromyalgia.
  • The participant has a concomitant comorbid skin condition that, in the opinion of the investigator, would interfere with the study assessments, such as evidence of non-plaque PsO (erythrodermic, pustular, predominately guttate PsO, inverse, or drug-induced PsO).

Recruiting US locations

  • AARR- Chandler AZ

    Chandler, AZ 85225

    Site contact: Site Contact · 480-443-8400 · al-khoudari.research@azarthritis.com

  • Arizona Arthritis & Rheumatology Research, PLLC | Phoenix, AZ

    Phoenix, AZ 85032

    Site contact: Site Contact · 480-443-8400 · chohan.research@azarthritis.com

  • Arizona Arthritis & Rheumatology Research, PLLC | Phoenix, AZ

    Phoenix, AZ 85032

    Site contact: Site Contact · 602-386-4972 · soloman.research@azarthritis.com

  • First OC Dermatology Research Inc.

    Fountain Valley, CA 92708

    Site contact: Site Contact · 714-531-2966 · vivian.laquer@firstocdermresearch.com

  • Purushotham & Akther Kotha MD

    La Mesa, CA 91942

    Site contact: Site Contact · 619-229-1995 · roshankotha@gmail.com

  • Triwest Research Associates LLC

    La Mesa, CA 91942

    Site contact: Site Contact · 619-334-4735 · drmabaquiao@triwestresearch.com

  • The Cohen Medical Centers

    Thousand Oaks, CA 91360-3967

    Site contact: Site Contact · 805-728-0050 · Scohen@sclamanagement.com

  • Foothill Arthritis Clinic

    Tujunga, CA 91042

    Site contact: Site Contact · 213-281-5146 · vipul@medvinresearch.com

  • Denver Arthritis Clinic | Denver, CO

    Denver, CO 80230

    Site contact: Site Contact · 303-394-2828 · rantolini@dacdenver.com

  • Arthritis & Rheumatic Disease Specialties (AARDS)

    Aventura, FL 33180

    Site contact: Site Contact · 305-652-6676 · drnbg@rheum.com

  • RASF- Clinical Research Center

    Boca Raton, FL 33486-1390

    Site contact: Site Contact · 5651-361-6547 · sbb61@aol.com

  • Clinical Research of West Florida | Clearwater, FL

    Clearwater, FL 33765

    Site contact: Site Contact · 727-466-0078 · rlevin@crwf.com

  • GNP Research, LLC | Hollywood, FL

    Cooper City, FL 33024

    Site contact: Site Contact · 754-248-3589 · mjaffe@gnpresearch.com

  • Tectum Medical Research

    Davie, FL 33024

    Site contact: Site Contact · 954-704-1050 · Lilliam.miranda@tectumresearch.com

  • Sweet Hope Research Specialty, Inc, d/b/a Neoclinical Research

    Hialeah, FL 33016

    Site contact: Site Contact · 305-456-9062 · csesin1979@aol.com

  • Bioresearch Partners

    Miami, FL 33143

    Site contact: Site Contact · 833-489-4968 · okromomd@bioresearchpartner.com

  • Millennium Research | Ormond Beach, FL

    Ormond Beach, FL 32174

    Site contact: Site Contact · 386-672-1985 · drkohen1@gmail.com

  • IRIS Research and Development | Plantation, FL

    Plantation, FL 33324

    Site contact: Site Contact · 954-476-2338 · drvalenzuela@irisrheumatology.com

  • Sarasota Arthritis Research Center

    Sarasota, FL 34239

    Site contact: Site Contact · 941-365-0770 · jboodoo@arthritiscenters.net

  • West Broward Rheumatology Associates, Inc.

    Tamarac, FL 33321

    Site contact: Site Contact · 954-724-5560 · wbral.ramrattan@gmail.com

  • Clinical Research of West Florida | Tampa, FL

    Tampa, FL 33606

    Site contact: Site Contact · 813-870-1292 · jcarter@crwf.com

  • Marietta Rheumatology Associates

    Marietta, GA 30060

    Site contact: Site Contact · 770-372-3962 · rquerubin@csi-research.com

  • GSCP/CIS

    Orland Park, IL 60467

    Site contact: Site Contact · 847-599-2492 · cconniff@cisresearch.com

  • Greater Chicago Specialty Physicians LLC/CIS

    Schaumburg, IL 60195

    Site contact: Site Contact · 847-599-2492 · kchaudhary@cisresearch.com

  • Accurate Clinical Research, Inc. | Lake Charles

    Lake Charles, LA 70605

    Site contact: Site Contact · 337-312-8617 · emendezmd@accurateclinicalresearch.com

  • Klein & Associates, M.D., P.A.

    Hagerstown, MD 21740

    Site contact: Site Contact · 301-724-4337 · mhowell@rheumdocs.com

  • Michigan Rheumatology Group, P.C. - Grand Blanc Office

    Grand Blanc, MI 48439-2451

    Site contact: Site Contact · 810-694-0082 · akarrar@aamrc.net

  • Ash Research Clinic - Howell

    Howell, MI 48843

    Site contact: Site Contact · mir.asghar@ashresearchclinic.com

  • June DO, PC Private Practice - Dr. Justus Fiechtner

    Lansing, MI 48911-4285

    Site contact: Site Contact · 517-272-9727 · joshua.june@glcor.com

  • Clinical Research Institute of Michigan

    Saint Clair Shores, MI 48081

    Site contact: Site Contact · 586-598-3329 · asulich@msn.com

  • Saint Louis Rheumatology

    St Louis, MO 63119

    Site contact: Site Contact · 314-646-0688 · cronholm@stlrheum.com

  • Albuquerque Center for Rheumatology PC

    Albuquerque, NM 87102-1710

    Site contact: Site Contact · 505-242-6190 · leroyp@abqrheum.net

  • Santa Fe Rheumatology

    Santa Fe, NM 87505-1102

    Site contact: Site Contact · 505-988-7568 · drnorton@inspiresantafe.com

  • NYU Langone Health | Joseph S. and Diane H. Steinberg Ambulatory Care Center - Rheumatology Department

    Brooklyn, NY 11201

    Site contact: Site Contact · 347-390-7798 · davidgoddardpi@gmail.com

  • Accellacare of Hickory

    Hickory, NC 28602

    Site contact: Site Contact · 828-345-5060 · rdc3s@yahoo.com

  • University Hospitals | UH Cleveland Medical Center - Department of Medicine - Rheumatology Division

    Cleveland, OH 44106

    Site contact: Site · 216-286-1246 · marina.magrey@uhhospitals.org

  • Paramount Medical Research & Consulting, LLC

    Middleburg Heights, OH 44130

    Site contact: Site Contact · 440-826-0742 · idiabmd@gmail.com

  • PA Regional Center for Arthritis and Osteoporosis Research

    Wyomissing, PA 19610-3206

    Site contact: Site Contact · 610-374-8133 · gemkeyresearch@emkeyarthritis.com

  • West Tennessee Research Institute

    Jackson, TN 38305

    Site contact: Site Contact · 731-633-0145 · aresearch@arthritisclinic.org

  • Accurate Clinical Research

    Baytown, TX 77521

    Site contact: Site Contact · 832-705-7839 · snajammd@accurateclinicalresearch.com

  • Novel Research | Bellaire Location

    Bellaire, TX 77024

    Site contact: Site Contact · 832-757-8490 · neiman@novelresearch.net

  • Novel Research | Bellaire Location

    Bellaire, TX 77024

    Site contact: Site Contact · 832-400-2262 · wajeeha@novelresearch.net

  • Accurate Clinical Research

    Houston, TX 77089

    Site contact: Site Contact · 281-240-1045 · pwallermd@accurateclinicalresearch.com

  • Introscience Research | Northwest Houston Arthritis Center - Houston, TX

    Houston, TX 77090

    Site contact: Site Contact · 832-834-5627 · adnan@novelresearch.net

  • West Texas Clinical Research

    Lubbock, TX 79424

    Site contact: Site Contact · 806-993-1040 · jitendra.vasandani@yahoo.com

  • Southwest Rheumatology Research, LLC | Mesquite, TX

    Mesquite, TX 75150

    Site contact: Site Contact · 972-288-2600 · asinghal@swrr.net

  • Clinical Investigations of Texas

    Plano, TX 75075

    Site contact: Site Contact · 972-599-1530 · Fehmida.zahabi@citplano.com

  • Arthritis Northwest, PLLC | Spokane, WA

    Spokane, WA 99204

    Site contact: Site Contact · 509-838-6500 · tcone@arthritisnw.com

Study contacts (from the official record)

  • Takeda Contact · +1-877-825-3327 · medinfoUS@takeda.com
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