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LATe Cerclage in High-risk Pregnancies (LATCH)

Thomas Jefferson University · NCT06036446

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–50 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
329
US sites recruiting
2
Study start
November 10, 2023
Record last updated
May 29, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to determine whether cervical cerclage reduces the risk of preterm birth in patients with a short transvaginal ultrasound (TVU) cervical length (CL) ≤25mm between 24 0/7-26 6/7 weeks.

Being studied: Cervical cerclage; Vaginal Suppository Progesterone

Conditions: Premature Birth

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 18-50 years old, pregnant, assigned female at birth
  • Singleton pregnancy
  • TVU CL ≤25mm between 24 0/7 - 26 6/7 weeks of gestation

Exclusion Criteria

  • Initial multifetal gestation with subsequent multifetal pregnancy reduction, or selective fetal termination performed >14 weeks, or cotwin pregnancy loss diagnosed >14 weeks
  • Cerclage in situ
  • Preterm labor, defined as painful regular uterine contractions and change in cervical dilation
  • PPROM
  • Active vaginal bleeding
  • Suspected intraamniotic infection
  • Major fetal structural abnormality or chromosomal disorder
  • Placenta previa or accreta
  • Other contraindication to cerclage placement
  • Participation in another clinical trial related to preterm birth prevention, cerclage, or progesterone

Recruiting US locations

  • Atrium Health Carolinas Medical Center

    Charlotte, NC 28204

    Site contact: Lorene Temming, MD, MSCI · 704-448-0305 · Lorene.Temming@advocatehealth.org

  • Thomas Jefferson University

    Philadelphia, PA 19107

    Site contact: Moti Gulersen, MD, MSc · 215-955-5000 · moti.gulersen@jefferson.edu

Study contacts (from the official record)

  • Moti Gulersen, MD, MSc · 215-955-5000 · moti.gulersen@jefferson.edu
  • Vincenzo Berghella, MD · 215-955-5000 · vincenzo.berghella@jefferson.edu
All pregnancy studies in North Carolina →
LATe Cerclage in High-risk Pregnancies (LATCH) (NCT06036446) | Bored Studies