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Manipulating E-Cigarette Nicotine to Promote Public Health

Ohio State University Comprehensive Cancer Center · NCT06448351

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21–65 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
375
US sites recruiting
1
Study start
May 20, 2024
Record last updated
August 14, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This clinical trial explores the manipulation of e-cigarette (EC) nicotine to promote public health. Researchers are trying to understand and gather information about how the strength, form, and structure of nicotine in products play a significant role in their potential for addiction and how they might affect health risks. The information gained from this study may allow researchers to understand how these aspects of nicotine influence the potential for addiction, how people puff on ECs, how the body processes nicotine, and any potential harmful effects it might have on health. Exploring these specific characteristics of nicotine may also determine if an EC product standard could help identify optimal nicotine levels for users.

Being studied: Biospecimen Collection; Carbon Monoxide Measurement; Vaping session; Survey Administration

Conditions: Tobacco-Related Carcinoma

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Current exclusive young adult EC user for at least the past 3 months (confirmed by cotinine testing strip) between 21-24 years old with no/minimal history of smoking cigarettes (≤ 10 cigarettes in entire life)
  • Current older adult smoker (daily use, ≥ 100 cigarettes in entire life) aged 25-65 with interest in trying an EC
  • Willing to abstain from all nicotine, tobacco products, and marijuana for at least 12 hours for Study 1 and 2 hours for Study 2 before study visits
  • Read, write, and speak English

Exclusion Criteria

  • Currently attempting to quit nicotine or tobacco products
  • Currently pregnant (will be verified with urine pregnancy test), planning to become pregnant, or breastfeeding
  • If age 21-24 years old AND use of any tobacco products other than ECs (use of >10 cigarettes in entire life; use of >10 traditional cigars, cigarillos, or filtered cigars in entire life; use of smokeless tobacco products >10 times in entire life; or hookah in the last 30 days).
  • Self-reported diagnosis of lung disease including asthma, cystic fibrosis, or chronic obstructive pulmonary disease
  • New or unstable cardiovascular disease diagnosed within the past 3 months
  • Use of medications that are inducers of CYP2A6 enzyme such as rifampicin, dexamethasone, phenobarbital, and other anti-convulsion drugs

Recruiting US locations

  • Ohio State University Comprehensive Cancer Center

    Columbus, OH 43210

    Site contact: Theodore L. Wagener, PhD · 844-744-2447 · ccc-tobacco@osumc.edu

All smoking & vaping studies in Ohio →
Manipulating E-Cigarette Nicotine to Promote Public Health (NCT06448351) | Bored Studies