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Maternal Autoimmune Disease Research Alliance (MADRA) Registry

Duke University · NCT03276923

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Any age listed · Women only
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
1000
US sites recruiting
1
Study start
January 1, 2018
Record last updated
January 8, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This multi-site registry, centered at Duke University, will enroll pregnant women with autoimmune and rheumatologic diseases.

The main goal of MADRA is to identify ways to improve the health of women with rheumatic diseases and their babies during pregnancy.

Prior studies demonstrate the importance of increase inflammation prior to and during pregnancy on these outcomes. The future research will seek to better define these risk factors and to identify ways to may improve them.

Conditions: Autoimmune Diseases; Pregnancy Related; Systemic Lupus Erythematosus; Cutaneous Lupus; Rheumatoid Arthritis; Sjogren's Syndrome; Scleroderma

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Desire for pregnancy within 6 months or currently pregnant
  • Women with systemic autoimmune disease, including:
  • Lupus (systemic lupus erythematosus or cutaneous lupus)
  • Antiphospholipid Syndrome or positive antiphospholipid antibodies
  • Rheumatoid Arthritis
  • Scleroderma (systemic sclerosis)
  • Sjogren's Syndrome
  • Inflammatory Arthritis (including Psoriatic Arthritis and Ankylosing Spondylitis)
  • Undifferentiated Connective Tissue Disease (UCTD)
  • Vasculitis
  • Myositis (Polymyositis or Dermatomyositis)
  • Positive Ro/SSA or La/SSB antibodies

Exclusion Criteria

  • Unable to speak English
  • Unable to provide informed consent
  • Unable to travel to Duke University for follow-up visits

Recruiting US locations

  • Duke University

    Durham, NC 27705

    Site contact: Megan Clowse, MD · 919 681 2045 · megan.clowse@duke.edu

Study contacts (from the official record)

  • Laura Neil · 919 684 8936 · laura.k.neil@duke.edu
  • Edna Scarlett · 919-684-6150 · edna.scarlett@duke.edu
All pregnancy studies in North Carolina →
Maternal Autoimmune Disease Research Alliance (MADRA) Registry (NCT03276923) | Bored Studies