Menstrual Cup for Early Endometrial Cancer Detection in Lynch Syndrome

Study Goal

This pilot study wants to find out if using a menstrual cup can be a good, non-invasive way to collect samples from the lining of the uterus (called the endometrium) to help screen for endometrial cancer. This is especially important for women who have a higher chance of getting this cancer, such as those with a genetic condition called Lynch syndrome.

Main Questions the Study Will Answer

• Can a menstrual cup collect enough uterine lining (endometrial tissue) for doctors to examine under a microscope?
• Are the samples from the menstrual cup as useful for diagnosis as samples taken using the usual method (called an endometrial biopsy or EMB)?
• Is using a menstrual cup at home easy, effective, and comfortable for participants?
• Can scientists grow small lab models of the uterus (called organoids) from the menstrual cup samples and from biopsy samples?

What Will Happen in the Study

• Participants will use a menstrual cup at home to collect menstrual blood.
• They will also have a standard endometrial biopsy done by a healthcare provider.
• After both collections, participants will fill out a short survey about how comfortable and easy it was to use the menstrual cup.

What the Study Will Measure

• Feasibility: How well participants are able to use the menstrual cup and send in the sample.
• Sample Quality: Whether the menstrual cup collects enough good-quality tissue for testing, and how it compares to biopsy samples.
• Participant Experience: How women feel about using the menstrual cup, based on the survey.
• Lab Testing: Whether researchers can successfully grow endometrial organoids from both types of samples.

Why This Study Matters: If this method works, it could offer a gentler, more convenient way for women to get checked for endometrial cancer-especially those who need regular screening. It could also make it easier to collect samples for research and improve early detection of cancer.