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Metabolic Health, Bones and Nuts During Weight Loss in Adults

Rutgers, The State University of New Jersey · NCT06949280

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 50–75 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
44
US sites recruiting
1
Study start
October 30, 2025
Record last updated
May 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group. Legumes, such as peanuts, are a plant-based food high in protein and unsaturated fat making this a healthy choice but are not consumed frequently enough in older adults. Studies have shown that regular nut consumption is associated with lower adiposity and reduced weight gain, and several dietary pattern studies indicate that nuts and legumes are associated with better bone health. In addition, our preliminary translational data indicates that a higher monounsaturated fatty acid (MUFA) intake is associated with improved bone mineral density (BMD) and quality. Given these findings, the proposed study aims to examine the impact of consuming peanut products on bone health, metabolic health (e.g., serum glucose, insulin, lipids and inflammation), markers of brain and sleep health, and physical function in overweight and obese older adults before and after a six-month weight loss intervention using a randomized controlled design. The results of this study have the potential to provide valuable insights into the role of peanuts as a sources of fatty acids in promoting health and preventing disease in at-risk adults.

Being studied: Peanut Snack Experimental; Nut-free Snack

Conditions: Weight Loss; Bone Density; Obesity and Overweight

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Men and postmenopausal women (>2 years since last menses), ages 50-75 years
  • Body mass index (25-42 kg/m2) or evidence of pre-clinical obesity.
  • Agree to be randomly assigned to consume a daily peanut snack or nut-free snack for 24 weeks
  • Must attend on-site visits (about 10) in New Brunswick, NJ, USA (transportation/reimbursement for travel not included)

Exclusion Criteria

  • Peanut allergies or intolerances
  • Participants with >5% weight loss in the past 6 months or extreme dietary/physical activity habits
  • An inability to follow the experimental intervention or to perform the required specimen collections.
  • Individuals with significant psychiatric or food disorders.
  • Current diagnosis, or history of cancer in past 3 years.
  • Current diagnosis or history of bone diseases, type I or II diabetes, gastrointestinal disease, hyperparathyroidism, untreated thyroid disease, significant immune, hepatic, cardiac, or renal disease.
  • Uncontrolled hypertension or hyperlipidemia in abnormal ranges.
  • History of surgery in the past 6 months or surgical procedure for weight loss in the past 3 years.
  • Regular use of medications that affect bone metabolism, including bisphosphonates or hormone replacement.
  • Regular use of medications for that affect the gastrointestinal tract including incretin mimetics, cholecystitis, urinary tract infection, severe organic diseases including coronary heart disease, myocardial infarction, infectious diseases including pulmonary tuberculosis and AIDS.
  • Antibiotic use in the past month
  • Alcohol or illicit drug abuse
  • Any other condition deemed by the Research Physician that would prevent participation in the study, e.g. participation in another clinical research project that may interfere with the results of this study.
  • Participation in another clinical interventional research trial

Recruiting US locations

  • Rutgers University - NJ Inst Food Nutrition & Health

    New Brunswick, NJ 08901

    Site contact: Principal Investigator · 848-932-9403 · shapses@rutgers.edu

Study contacts (from the official record)

  • Principal Investigator · 848-932-9403 · shapses@rutgers.edu
  • Research Manager · ru-nextnutrition@sebs.rutgers.edu
All weight loss studies in New Jersey →
Metabolic Health, Bones and Nuts During Weight Loss in Adults (NCT06949280) | Bored Studies