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Molecular Imaging of the Underlying Mechanism of Vessel Wall Inflammation Using Positron Emission Tomography (PET/CT)

University of Pennsylvania · NCT07548099

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
30
US sites recruiting
1
Study start
April 30, 2026
Record last updated
May 22, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This research study is being conducted to test how an imaging drug called 64Cu-DOTA-ECL1i can be used to image an abdominal aortic aneurysm. 64Cu-DOTA-ECL1i is a drug used with an imaging test called a PET/CT (Positron Emission Tomography/Computed Tomography).

The aim is to collect data using a new imaging drug called 64Cu-DOTA-ECL1i that may be able to create images of inflammation in the aorta, which is thought to be important in how aneurysms grow and develop and to understand how consistent these scans are across time and what might affect the inflammation.

Being studied: 64Cu-DOTA-ECL1i

Conditions: Abdominal Aortic Aneurysm

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Participants will be at least 18 years of age
  • Have an established diagnosis of abdominal aortic aneurysm based on standard clinical criteria or are an age matched control with absence of known AAA.
  • Participants must be informed of the investigational nature of this study and be willing to provide written informed consent and participate in this study in accordance with institutional and federal guidelines prior to study-specific procedures.

Exclusion Criteria

  • Females who are pregnant or breast feeding at the time of the PET/CT scan will not be eligible for this study; a urine pregnancy test will be performed in women of child-bearing potential before the injection of radiotracer.
  • Inability to tolerate imaging procedures in the opinion of an investigator or treating physician
  • Patients with chronic renal disease whose GFR is less than 40 mL/min/1.73m² at the time of enrollment.
  • Documented allergy to iodinated contrast
  • Any current medical condition, illness, or disorder as assessed by medical record review and/or self-reported that is considered by a physician investigator to be a condition that could compromise participant safety or successful participation in the study
  • Less than 6 months life expectancy as deemed by the treating physician at the time of initial enrollment.

Recruiting US locations

Study contacts (from the official record)

  • Erin Schubert · 215-573-6569 · erin.schubert@pennmedicine.upenn.edu
  • Mary Hansbury · 215-746-8192 · mary.hansbury@pennmedicine.upenn.edu
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Molecular Imaging of the Underlying Mechanism of Vessel Wall… (NCT07548099) | Bored Studies