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MS-ResearchBiomarkerS

Cedars-Sinai Medical Center · NCT05204459

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
1000
US sites recruiting
1
Study start
November 11, 2021
Record last updated
February 6, 2024

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study is being conducted to investigate risk factors for disability progression in Multiple Sclerosis and related disorders (MSRD). The primary goal is to assess whether combining information from visual assessment, blood markers, as well as historical and ongoing longitudinal MRIs of the brain, orbit (the part of the skull where eyes are located), and/or spinal cord can predict changes in quantitative disability measures related to MSRD and neurological disease.

Conditions: Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Multiple Sclerosis, Primary Progressive; Multiple Sclerosis, Secondary Progressive; Clinically Isolated Syndrome; Radiologically Isolated Syndrome; Neuromyelitis Optica Spectrum Disorders; Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease; Neurologic Autoimmune Disease; Neurologic Disorder; Healthy Aging

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Subjects who meet any one of the following diagnostic criteria:
  • Diagnosis of MS, CIS,or RIS based on the 2017 revised McDonald criteria.
  • Diagnosis of NMOSD based on the 2015 revised NMOSD consensus diagnostic criteria.
  • Diagnosis of myelin oligodendrocyte glycoprotein (MOG)-related encephalomyelitis, optic neuritis, or other associated disease.
  • Diagnosis of neurological disorders other than MSRD.
  • Healthy volunteer.
  • Age ≥18.
  • Able to give informed consent.

Exclusion Criteria

  • Patients will be excluded from the MRI portions of the study if they have a contraindication to MRI(metallic implantsor foreign bodies, claustrophobia, MRI-incompatible pacemakers, MRI- incompatible prosthetic heart valves).
  • Patients will be excluded from the MRI portions of the study if they are pregnant, but their demographic, clinical information,and disability measures may still be captured under the study.
  • Patients will be excluded from the visual assessment portions of the study if they have had any recent ocular surgery (within the past two months), refractive errors of greater than or equal to ±6 diopters or other eye diseases that may affect or confound OCT/OCTA measurements (ex., age-related macular degeneration, advanced geographic atrophy, diabetic retinopathy, glaucoma).

Recruiting US locations

  • Cedars-Sinai Medical Center

    Los Angeles, CA 90048

    Site contact: Omar Al-Louzi, MD · 310-423-4008 · omar.allouzi@cshs.org

Study contacts (from the official record)

  • Omar Al-Louzi, MD · (310) 423-4008 · omar.allouzi@cshs.org
  • Group Neurology Research · (310)-423-6472 · GroupNeurologyMSProgramResearch@cshs.org
All neurology studies in California →
MS-ResearchBiomarkerS (NCT05204459) | Bored Studies