Neuromodulation and Neuroimaging in Older Children With Mild Traumatic Brain Injury

Experimental Cohort

Inclusion Criteria

• age 10-15 years at enrollment
• enrolled after 6 weeks of mTBI injury
• exhibiting post-concussive symptoms (e.g., difficulty planning, sequencing, and executing a motor action)
• Sustained an mTBI or concussion within the past 12 months
• Parent and child proficient in English

Healthy Controls Cohort

Inclusion Criteria

• 10 to 15 years old
• no concussion history
• Parent and child proficient in English

Experimental Cohort

Exclusion Criteria

• loss of consciousness > 30 minutes
• post-traumatic amnesia > 24 hours
• intracranial findings on clinical imaging
• history of developmental delay
• history of learning disability or ADHD
• Sustained a lower limb or upper limb injury that has not healed
• History of Seizures
• Noticeable skin lesions/burns or any other severe skin problems at the site of the electrodes before the start of the stimulation.
• Parent/guardian report metal implants anywhere in the head/ncek/body on the MRI screening form (see attached).
• Parent/guardian report shrapnel/bullets in the body on the MRI screening form.
• Parent/guardian report any electronic implant such as a cardiac pacemaker, cochlear implant, ventricular shunt, cardiac defibrillator, aneurysm clips, pacing wires, any implant held in place with a magnet, heart valve, or deep brain stimulator on the MRI screening form.
• Parent/guardian report a craniotomy or any other surgery in the past 6 weeks on the MRI screening form.
• Parent/guardian report being claustrophobic on the MRI screening form.
• Parent/guardian report and provide orbit x-ray after the eye injury involving a metal that the subject is cleared as indicated on the MRI screening form.
• Pregnant females as reported by parent/guardian on the pre-consent screening form. Pubertal/post-pubertal female participants14 and above will be provided a separate post-consent screening form at each MRI visit to ensure the female reports accurately without fear.

Healthy Controls Cohort

Exclusion Criteria

• diagnosed with developmental delay
• sustained a lower limb or upper limb injury that has not healed
• history of Learning Disability and/or ADHD
• Parent/guardian report metal implants anywhere in the head/ncek/body on the MRI screening form (see attached).
• Parent/guardian report shrapnel/bullets in the body on the MRI screening form.
• Parent/guardian report any electronic implant such as a cardiac pacemaker, cochlear implant, ventricular shunt, cardiac defibrillator, aneurysm clips, pacing wires, any implant held in place with a magnet, heart valve, or deep brain stimulator on the MRI screening form.
• Parent/guardian report a craniotomy or any other surgery in the past 6 weeks on the MRI screening form.
• Parent/guardian report being claustrophobic on the MRI screening form.
• Parent/guardian report and provide orbit x-ray after the eye injury involving a metal that the subject is cleared as indicated on the MRI screening form.
• Pregnant females as reported by parent/guardian on the pre-consent screening form. Post-pubertal females 14 and above will be provided a separate post-consent screening form at each MRI visit to ensure the female reports accurately without fear.