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Neuromodulation of Memory in Aging

Indiana University · with National Institute on Aging (NIA) · NCT05460468

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–75 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
150
US sites recruiting
1
Study start
March 28, 2024
Record last updated
August 11, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The proposed research will use closed-loop transcranial magnetic stimulation (TMS) based on individualized brain networks to establish parameters that can reliably control brain states. This will be tested in healthy aging and mild cognitive impairment (MCI) cohorts. The investigators will study network activation and neural oscillatory mechanisms underlying the network that regulates working memory and then target this network using closed-loop TMS to the Prefrontal Cortex. Investigators will measure the impact of TMS on working memory performance and task-based neural activity. The project will use brain stimulation and network modeling techniques to enhance working memory in healthy older adults and MCI and will demonstrate the value of closed-loop, network-guided TMS for future clinical applications.

Being studied: Transcranial Magnetic Stimulation

Conditions: Mild Cognitive Impairment; MCI

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • English Speaking
  • Willing to provide consent

Exclusion Criteria

  • History of any Axis I DSM-V disorder, excluding major depressive disorder or generalized anxiety disorders
  • Current history of substance abuse or dependence (excluding nicotine)
  • Intracranial implants (e.g. aneurysms clips, shunts, stimulators, cochlear implants, or electrodes), cardiac pacemakers, or vagus Nerve stimulation device
  • Increased risk of seizure for any reason, including prior diagnosis of epilepsy, seizure disorder, increased intracranial pressure, or history of significant head trauma with loss of consciousness for ≥ 5 minutes.
  • Neurological disorder including, but not limited to: space occupying brain lesion; any history of seizures, history of cerebrovascular accident; fainting, cerebral aneurysm, Dementia, Hungtington chorea; Multiple Sclerosis.
  • Current use of medications known to lower the seizure threshold and/or affect working memory

Recruiting US locations

  • Duke University Hospital

    Durham, NC 27710

    Site contact: Simon Davis, PhD · 9196680437 · simon.davis@duke.edu

Study contacts (from the official record)

  • Simon W Davis, PhD · 9196841243 · simon.davis@duke.edu
  • Emily Finch, BA · 9196682842 · emily.finch@duke.edu
All neurology studies in North Carolina →
Neuromodulation of Memory in Aging (NCT05460468) | Bored Studies