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Neuromodulation to Improve Grasping Function After SCI

State University of New York at Buffalo · NCT07433959

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–75 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
54
US sites recruiting
1
Study start
April 1, 2026
Record last updated
April 23, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this study is to restore the activities of late descending signals with a noninvasive stimulation approach in combination with hand motor training to improve hand function in persons with cervical SCI. The main question it aims to answer is if the inputs to late descending signals above the level of injury and the output of residual late descending signals below the level of injury could be increased. Specifically, in the first part of the study, 30 participants will complete 2 randomized sessions to compare the effect of intermittent theta burst stimulation combined with paired corticospinal motoneuronal stimulation. In the second part of the study, 24 participants will complete either combined stimulation protocol or sham stimulation protocol with exercise training.

Being studied: iTBS; Sham iTBS; PCMS; Sham PCMS; Exercise

Conditions: Spinal Cord Injury

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

For individuals with SCI

  • Ages 18-75 years
  • Chronic SCI (≥1 year of injury)
  • Cervical injury at C8 or above
  • Individuals who have MEP responses in at least one FDI muscle

Exclusion Criteria

  • Uncontrolled medical problems including pulmonary or cardiovascular disease
  • Premorbid, ongoing major depression or psychosis, altered cognitive status
  • History of head injury or stroke
  • Metal plate in skull
  • History of seizures
  • Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs
  • Pregnant females
  • Individuals who suffer from a spinal cord disease such as spinal stenosis, spinal bifida or herniated cervical

Recruiting US locations

  • The State University of New York at Buffalo

    Buffalo, NY 14214

    Site contact: Karen Barnes · 716-829-6718 · barneska@buffalo.edu

Study contacts (from the official record)

  • Hang Jin Jo, PhD · 716-829-2905 · hangjinj@buffalo.edu
All healthy volunteers studies in New York →
Neuromodulation to Improve Grasping Function After SCI (NCT07433959) | Bored Studies