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Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage

Massachusetts General Hospital · with Fondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT07614906

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
40
US sites recruiting
1
Study start
March 3, 2024
Record last updated
May 29, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this observational study is to understand if angiographic cerebral vasospasm (CV) can be predicted by levels of nitric oxide (NO) consumption in patients with aneurysmal subarachnoid hemorrhage (SAH). To reach this goal, the investigators will compare NO consumption levels in SAH and non-SAH patients. NO consumption levels will be analyzed from samples of participants' cerebral spinal fluid (CSF).

Conditions: Aneurysmal Subarachnoid Hemorrhage; Cerebral Vasospasm

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adult
  • patient with SAH and with an external ventricular drainage (EVD) placed within 24 hours after the onset of the hemorrhage

Exclusion Criteria

  • pregnancy
  • pre-existing neurological comorbidities
  • coagulation disorders
  • anemia
  • absence of a good cranial window to perform Transcranial Doppler (TDC)
  • presence of >50% stenosis of carotid arteries confirmed by doppler ultrasound
  • Technical problems on EVD that prevent CSF withdrawals

For the control group, we will invite to participate patients without neurological comorbidities undergoing spinal anesthesia in the operating room or with a spinal drain for major vascular surgery.

Recruiting US locations

  • Massachusetts General Hospital

    Boston, MA 02114

    Site contact: Lorenzo Berra, MD · 617-726-3030 · lberra@mgh.harvard.edu

Study contacts (from the official record)

  • Lorenzo Berra, MD · 617-726-3030 · lberra@mgh.harvard.edu
All healthy volunteers studies in Massachusetts →
Nitric Oxide Consumption as a Predictor of Vasospasm in… (NCT07614906) | Bored Studies