Non-invasive Liquid Biopsy Analysis of Epigenomics Signatures in Multiple Cancer Types

Inclusion Criteria

• Subjects must be between 21-80 years of age at the time of enrollment
• Patient fully consented
• Cancer diagnosis OR high clinical suspicion for cancer, based on the participating site's and practitioner's standards of care (SOC)
• No previous history of cancer and treatment naïve at time of enrollment

Exclusion Criteria

• Age \< 21 OR > 80 years of age
• Any prior cancer diagnosis with or without treatment (with the exception of non-melanoma skin cancers resolved/treated > 1 year prior to enrollment)
• Receipt of any cancer therapy including chemotherapy, radiation, palliative radiation, hormonal or naturopathic therapies
• In situ carcinoma without an invasive component
• Any surgery requiring general anesthesia within 2 months of collection. Anesthesia used in procedures such as colonoscopy and EBUS is acceptable.
• Receipt of systemic immunomodulation therapy within past 12 months
• Currently pregnant, or pregnancy within last 12 months
• Organ transplantation
• Received dialysis
• Blood transfusion within 1 month
• Known HIV/AIDs, Hepatitis A, D, or E, TB, any kind of prion disorder (e.g., CJD) or other infectious pathogens currently present or present in past 5 years.