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Non-invasive Vagus Nerve Stimulation (nVNS) and Cognition in Young Adult Vapers - A Pilot Study

Temple University · NCT06804109

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–25 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
100
US sites recruiting
1
Study start
March 18, 2025
Record last updated
March 6, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to assess the effects of non-invasive vagus nerve stimulation (nNVS) on cognitive functioning in the users of e-cigarettes or vaping products. The investigators will use a digital wellness companion product (TRUVAGA™ device) that provides mild transcutaneous nVNS. The participants will be randomized to receive either a 2-min nNVS stimulation or control stimulation in the neck region followed by completion of three cognitive tests of attention and executive function.

Being studied: Active nVNS; Control nVNS

Conditions: Vaping

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Healthy young adults
  • Age range 18-25 years
  • Current or prior users of e-cigarettes

Exclusion Criteria

Participants will be excluded from the study if they:

  • Have any rash, infection, swelling, cut, soreness, drug patch, surgical scar on the neck area
  • Have any implantable medical device in their body such as a pacemaker, hearing aid implant, or any other metallic/electronic device
  • Have any hearing or vision problems that are not corrected
  • Are pregnant or breastfeeding
  • Have any learning disabilities
  • Have a medical history of any of the following condition
  • Meningitis
  • Traumatic brain injury
  • Seizure
  • Syncope
  • Schizophrenia
  • Schizoaffective disorder
  • Bulimia (eating disorder)
  • Other serious neurological illness
  • Have a medical history of any of the following cardiac disorder
  • Carotid atherosclerosis or carotid artery disease
  • Cervical vagotomy
  • First degree atrioventricular block or prolonged QT interval
  • Are taking any medications for to treat hypertension, arrhythmias, or are on calcium channel blockers

Recruiting US locations

Study contacts (from the official record)

  • Vinay Parikh, PhD · 215-204-1572 · vinay.parikh@temple.edu
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Non-invasive Vagus Nerve Stimulation (nVNS) and Cognition in Young… (NCT06804109) | Bored Studies