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Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2

Stanford University · NCT05833217

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–80 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
55
US sites recruiting
1
Study start
June 6, 2023
Record last updated
December 4, 2024

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The investigators are studying the pathophysiologic links between obesity, insulin resistance (IR), adipose tissue infection, and post-acute sequelae of COVID-19 (PASC). This study looks at whether adipose (fat) tissue contributes to PASC by driving chronic inflammation or by serving as a reservoir for SARS-CoV-2 persistence. The results will not only determine whether obesity and IR are risk factors for PASC, but will also define fundamental biology that sets the stage for the investigation of novel or existing therapies that target the causal pathways identified.

Being studied: Adipose Tissue Biopsy; Steady State Plasma Glucose (SSPG) Test

Conditions: Long COVID; Insulin Resistance; Insulin Sensitivity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Ages 18 to 80
  • BMI ≥ 25 kg/m2
  • not currently pregnant

Exclusion Criteria

Arm 2 (Adipose Tissue Biopsy) exclusions include

  • pregnancy
  • prior liposuction
  • recent change in weight (> 2 kg in one month)
  • bleeding disorders
  • anticoagulant use

Arm 3 (healthy controls only) exclusions include patients with

  • major organ disease
  • diabetes
  • history of liposuction
  • bariatric surgery
  • eating disorders
  • psychiatric disorders
  • pregnancy or lactation
  • recent change in weight (over the past 12 weeks),
  • use of weight loss medication or oral steroids
  • hematocrit \< 33%
  • fasting glucose >= 126 mg/dL
  • blood pressure >160/100 mmHg

Recruiting US locations

  • Stanford Health

    Palo Alto, CA 94305

    Site contact: Nicole Turk, BS · 650-888-0144 · nturk@stanford.edu

Study contacts (from the official record)

  • Nicole Turk, BS · 6508880144 · nturk@stanford.edu
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Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2 (NCT05833217) | Bored Studies