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OCT Vibrography for Biomechanical Properties of Tissues

Massachusetts General Hospital · with Massachusetts Eye and Ear Infirmary · NCT05759780

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–75 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
90
US sites recruiting
1
Study start
August 19, 2023
Record last updated
October 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo.

Being studied: Optical imaging of the tissues

Conditions: Cornea; Skin Diseases; Gingival Diseases

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Group 1:

Inclusion criteria

  • Subjects with healthy eyes (age 18 - 75, N = 50)

Exclusion criteria

  • Subjects with history of eye diseases, and previous eye surgeries.
  • Subjects with diabetes, glaucoma family history
  • Subjects allergic to anesthetic eyedrop, especially proparacaine
  • Subjects with severe allergy
  • Subjects who have difficulty biting
  • Subjects who have recurrent corneal erosion

Group 2:

Inclusion criteria

  • Subjects with healthy skin (age 18 - 75, N = 10)

Exclusion criteria

  • Subjects with open cuts/sores on the skin, skin infection, or any contagious skin condition

Group 3:

Inclusion criteria

  • Subjects with healthy gingiva (age 18 - 75, N = 10)

Exclusion criteria

  • Subjects with open cuts/sores on the gingiva, gingiva infection, or any contagious gingiva condition

Group 4:

Inclusion criteria

  • Mild or moderate keratoconus subjects (age 18 - 40, N = 20)

Exclusion criteria

  • Subjects with K-max above 60 diopters (Pentacam imaging) are excluded

Recruiting US locations

  • Massachusetts General Hospital

    Boston, MA 02114

    Site contact: Jing Zhang, PhD · 6173730127 · jzhang110@mgh.harvard.edu

Study contacts (from the official record)

  • Jing Zhang, PhD · 6173730127 · jzhang110@mgh.harvard.edu
  • Seok-Hyun Yun, PhD · 6177688704 · syun@mgh.harvard.edu
All healthy volunteers studies in Massachusetts →
OCT Vibrography for Biomechanical Properties of Tissues (NCT05759780) | Bored Studies