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Pistachio Snacking and Metabolic Flexibility

University of South Carolina · with American Pistachio Growers · NCT07340125

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 25–45 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
60
US sites recruiting
1
Study start
September 1, 2025
Record last updated
January 14, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.

Being studied: Pistachio

Conditions: Overweight (BMI > 25); Obese But Otherwise Healthy Participants; Overweight or Obese; Obese Patients (BMI ≥ 30 kg/m²); Poor Sleep Quality; Healthy Participants; Physically Inactive

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Males and Females
  • Age: 25-45 years
  • Overweight or obese (BMI=25.0-34.9 kg/m²)
  • Poor sleep quality (Pittsburgh Sleep Quality Index ≥ 5)
  • Healthy (no diagnosed metabolic, cardiovascular, sleep, or other health condition that may significantly alter metabolism, sleep, or ability to participate in the exercise test)
  • Not meeting weekly physical activity recommendations (\<150 min moderate-intensity exercise, \<75 minutes of vigorous-intensity exercise, and \<2 days of strength training)
  • Not following a diet that is restrictive or eliminates certain food group/types

Exclusion Criteria

  • Allergies to nuts, especially tree nuts
  • Has a pacemaker
  • Following a diet that is restrictive or eliminates certain food group/types
  • Self-repoted health or disease state that may influence study outcomes, including known metabolic or endocrine disorder (e.g. prediabetes, type 1 or type 2 diabetes, or polycystic ovary syndrome), cardiovascular diseases, neuromuscular disorders, musculoskeletal disorders; current or recent history of cancer/cancer treatment (within the past year)
  • History of gastrointestinal surgery, hysterectomy
  • For women: pregnant or thinking of becoming pregnant during the time of participation, pregnant within the last year, currently breastfeeding, or known to be perimenopausal

Recruiting US locations

  • Public Health Research Center: Clinical Exercise Research Center

    Columbia, SC 29208

Study contacts (from the official record)

  • Callie Unrein, MS · 803-777-5478 · sustainlab@mailbox.sc.edu
All weight loss studies in South Carolina →
Pistachio Snacking and Metabolic Flexibility (NCT07340125) | Bored Studies