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Polygenic Risk Scores and Multi-cancer Early Detection for Ovarian Cancer

Abramson Cancer Center at Penn Medicine · with Susan G. Komen Breast Cancer Foundation, Memorial Sloan Kettering Cancer Center · NCT06436248

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 25+ · Women only
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
24
US sites recruiting
1
Study start
July 1, 2024
Record last updated
October 30, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The overall goal of the Polygenic Risk Scores and Multi-cancer Early Detection for Ovarian Cancer (PROMISE) study is to better understand how women may incorporate both polygenic risk score (PRS) and novel early detection strategies in their decisions regarding cancer screening and risk reducing surgery. This study will conduct qualitative interviews to better understand women's attitudes regarding polygenic risk score (PRS) and early detection assays.

Conditions: Ovarian Cancer; BRCA Mutation

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Female, age 25 or older (given that women under this age are not generally recommended to receive BRCA1/2 genetic testing)
  • Completed full sequence or targeted genetic testing with a clinically confirmed BRCA1 or BRCA2 deleterious mutation identified.
  • English-fluent; the surveys and interviews were designed and validated in English and are not currently available in other languages. Translation of questionnaires into other languages would require reestablishing the reliability and validity of these measures. Therefore, participants must be able to communicate in English to complete the surveys.

Exclusion Criteria

  • Previous receipt of any prophylactic oophorectomy
  • Personal history of ovarian cancer
  • Major psychiatric illness or cognitive impairment that in the judgment of the study investigators would preclude study participation.
  • Any patients who are unable to comply with the study procedures as determined by the study investigators or study staff.

Recruiting US locations

  • Abramson Cancer Center

    Philadelphia, PA 19104

    Site contact: Jamie Brower, MS · 215-662-7245 · jabrower@pennmedicine.upenn.edu

Study contacts (from the official record)

  • Jamie Brower, MS · 215-662-7245 · jabrower@pennmedicine.upenn.edu
All healthy volunteers studies in Pennsylvania →
Polygenic Risk Scores and Multi-cancer Early Detection for Ovarian… (NCT06436248) | Bored Studies