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Potassium, Hydration, Cardiovascular, and Kidney Study (PHACKs)

Auburn University · with Indiana University · NCT06062017

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–30 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
40
US sites recruiting
1
Study start
November 6, 2024
Record last updated
February 27, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Compared with White Adults, Non-Hispanic Black Adults are at an elevated risk of developing cardiovascular disease (CVD) and end stage chronic-kidney disease (CKD), two of the leading causes of death in the United States. Inadequate hydration status is associated with risk factors for both CVD and CKD. Prior data show that Black individuals are less likely to be adequately hydrated when compared with their White counterparts. Further, socioeconomic factors have been shown to influence hydration practices. Inadequate hydration influences certain hormones that regulate blood volume and impact blood pressure, but increasing potassium intake may provide some positive effects on normalizing these hormones and blood pressure. Black adults, in particular, are more likely to consume less potassium, have inadequate hydration, and tend to have higher blood pressure. As such, there is a critical need for effective strategies to address racial disparities in hydration and resultant health consequences; as well as establish the role of socioeconomic factors contributing to hydration. Therefore, the investigators are seeking to test the investigators' central hypothesis that water with a potassium supplement will improve hydration and cardiovascular health in young White adults (n = 20, 10 females, 10 males), and to a greater extent in young Black Adults (n = 20, 10 females, 10 males. The investigators will assess measures of blood pressure, arterial stiffness, and biomarkers in the urine and blood samples prior to and following a 14-day hydration intervention of 1) bottled water and 2) bottled water with potassium supplementation (2000mg potassium/day).

Being studied: Water and Potassium supplementation

Conditions: Blood Pressure; Hydration; Vascular Disease Risk

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Between the ages of 18-30 years
  • Resting blood pressure no higher than 150/90 mmHg
  • BMI below 35 kg/m2
  • Free of any metabolic disease (e.g., diabetes) kidney disease, pulmonary disorders (e.g., COPD), cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular), no autoimmune diseases, and no history of cancer.

Exclusion Criteria

  • Have any precluding medical conditions (i.e. hemophilia) or medication (Pradaxa, Eliquis, etc.) that prevent participants from giving blood.
  • Are currently pregnant or trying to become pregnant.
  • take any of the following medications that are contraindicated with potassium supplementation:
  • Renin-angiotensin-aldosterone system (RAAS) blockers: Candesartan , Eprosartan, Irbesartan, Losartan, Olmesartan, Telmisartan
  • Non -steroidal anti-inflammatory medications: Aspirin, Ibuprofen, Naproxen
  • Non-selective beta-blockers: Pindolol, Penbutolol, Oxprenolol, Propranolol, Nadolol, Sotalol, Timolol, Tertatolol
  • Calcineurin inhibitors: Cyclosporine
  • Heparin (or other blood thinning medications)

Recruiting US locations

  • Kinesiology Building

    Auburn, AL 36849

    Site contact: Nina L Stute, MS · 334-844-1619 · nls0028@auburn.edu

Study contacts (from the official record)

  • Nina L Stute, M.S. · 9373071608 · NLS0028@auburn.edu
  • Meral A Culver, M.S. · 3017428813
Potassium, Hydration, Cardiovascular, and Kidney Study (PHACKs) (NCT06062017) | Bored Studies