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RecruitingPhase 2

A Clinical Trial of MK-7262 and Enlicitide in Participants With High Lipoprotein(a) (MK-7262-004)

Merck Sharp & Dohme LLC · NCT07614984

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 2
Target enrollment
750
US sites recruiting
24
Study start
June 30, 2026
Record last updated
October 23, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Researchers designed a trial medicine called MK-7262 to lower levels of Lp(a) in the blood. Researchers want to learn about giving MK-7262 with another trial medicine called enlicitide (also known as MK-0616 or enlicitide decanoate). Enlicitide is in a group of medicines that lower the amount of low-density lipoprotein cholesterol (LDL-C).

The goals of this trial are to evaluate

  • if MK-7262 and enlicitide taken together work better than placebo at lowering Lp(a) and LDL-C levels in the blood
  • if MK-7262 alone works better than placebo at lowering Lp(a) levels in the blood
  • the safety and tolerability of taking MK-7262 and enlicitide alone and together

Being studied: MK-7262; Enlicitide; Placebo for MK-7262; Placebo for enlicitide

Conditions: Lipoprotein(a)

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

The main inclusion criteria include but are not limited to the following:

  • Has Lp(a) ≥ 150 nmol/L
  • Is receiving an optimized and stable dose of statin for ≥ 30 days with no planned additions, dose changes, or discontinuations through the duration of the study

Exclusion Criteria

The main exclusion criteria include but are not limited to the following:

  • Has a history of homozygous familial hypercholesterolemia (FH), compound heterozygous FH, or double heterozygous FH
  • Has a history of class IV heart failure, severe ventricular systolic dysfunction, uncontrolled ventricular arrhythmia, markedly prolonged corrected QT interval, untreated hypertension, or a recent coronary, cerebrovascular, or peripheral ischemic event or arterial revascularization
  • Has human immunodeficiency virus infection, unless the infection is controlled (i.e. undetectable viral load)
  • Has an active hepatitis C virus infection or active or chronic hepatitis B virus infection
  • Has a history of nephrotic syndrome
  • Has severe renal insufficiency
  • Has received certain therapies in the prohibited timeframe as specified in the protocol
  • Has active or chronic hepatobiliary or hepatic disease
  • Has poorly controlled Type 1 or Type 2 diabetes

Recruiting US locations

  • Advanced Cardiovascular - Alexander City ( Site 0158)

    Alexander City, AL 35010

    Site contact: Study Coordinator · 256-215-5323

  • AMR Clinical Mobile ( Site 0149)

    Mobile, AL 36608

    Site contact: Study Coordinator · 251-414-1984

  • National Heart Institute ( Site 0113)

    Beverly Hills, CA 90211-2285

    Site contact: Study Coordinator · 310-289-5221

  • Headlands Research CTR Lincoln ( Site 0127)

    Lincoln, CA 95648

    Site contact: Study Coordinator · 916-434-8230

  • Chase Medical Research, LLC ( Site 0163)

    Waterbury, CT 06708

    Site contact: Study Coordinator · 203-419-4420

  • Soffer Health Institute ( Site 0123)

    Hollywood, FL 33020

    Site contact: Study Coordinator · 305-250-2106

  • Westside Center for Clinical Research ( Site 0161)

    Jacksonville, FL 32205

    Site contact: Study Coordinator · 904-693-1490

  • Inpatient Research Clinic ( Site 0110)

    Miami Lakes, FL 33014

    Site contact: Study Coordinator · 786-502-4303

  • Clinical Research Trials of Florida ( Site 0101)

    Tampa, FL 33607

    Site contact: Study Coordinator · 813-873-8102

  • Conquest Research LLC ( Site 0140)

    Winter Park, FL 32789

    Site contact: Study Coordinator · 407-916-0060

  • Flourish Research - Bowie ( Site 0106)

    Bowie, MD 20715

    Site contact: Study Coordinator · 410-824-1341

  • Velocity Clinical Research Rockville ( Site 0146)

    Rockville, MD 20854

    Site contact: Study Coordinator · 240-698-2800

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division ( Site 0132)

    Troy, MI 48098

    Site contact: Study Coordinator · 248-312-0025

  • Minneapolis Heart Institute - Minneapolis ( Site 0130)

    Minneapolis, MN 55407

    Site contact: Study Coordinator · 612-863-3833

  • Montana Medical Research, Inc. ( Site 0156)

    Missoula, MT 59808

    Site contact: Study Coordinator · 406-549-1124

  • New Mexico Clinical Research & Osteoporosis Center ( Site 0119)

    Albuquerque, NM 87106

    Site contact: Study Coordinator · 505-855-5505

  • Laurelton Heart Specialist PC ( Site 0155)

    Rosedale, NY 11422

    Site contact: Study Coordinator · 718-949-9400

  • Velocity Clinical Research, Durham ( Site 0145)

    Durham, NC 27701

    Site contact: Study Coordinator · 919-503-4711

  • Remington-Davis, Inc. ( Site 0107)

    Columbus, OH 43215

    Site contact: Study Coordinator · 614-487-2560

  • Holston Medical Group ( Site 0117)

    Kingsport, TN 37660

    Site contact: Study Coordinator · 423-857-2789

  • Center for Cardiometabolic Disease Prevention/Baylor College of Medicine ( Site 0154)

    Houston, TX 77030

    Site contact: Study Coordinator · 713-798-5800

  • DM Clinical Research ( Site 0115)

    Tomball, TX 77375

    Site contact: Study Coordinator · 346-550-9559

  • Carient Heart & Vascular - Manassas ( Site 0165)

    Manassas, VA 20109

    Site contact: Study Coordinator · 571-581-1771

  • Rainier Clinical Research Center ( Site 0116)

    Renton, WA 98057

    Site contact: Study Coordinator · 425-251-1720

Study contacts (from the official record)

  • Toll Free Number · 1-888-577-8839 · Trialsites@msd.com
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A Clinical Trial of MK-7262 and Enlicitide in Participants With… (NCT07614984) | Bored Studies