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RecruitingAccepts healthy volunteersPhase 2

Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery

United States Naval Medical Center, Portsmouth · NCT06488001

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–79 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Phase 2
Target enrollment
132
US sites recruiting
1
Study start
August 26, 2022
Record last updated
May 21, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to see if pantoprazole (a proton pump inhibitor used for acid reflux/heart burn) can reduce nausea and vomiting after gynecologic surgery in women between the ages of 18 and 79.

Researchers will compare a placebo to the active medication.

Participants will be asked to take three pills around their surgery, two taken before and one taken the night after.

Being studied: pantoprazole; Placebo

Conditions: Postoperative Nausea and Vomiting

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Undergoing elective gynecological surgery by either an open abdominal or minimally invasive approach (to include both endoscopic and vaginal). Procedure must be performed under general anesthesia.

Exclusion Criteria

  • Pregnant,
  • Patients with gastrointestinal disease requiring ongoing medical management.
  • Prior gastrointestinal surgery with the exception of diagnostic procedures, appendectomy and cholecystectomy.
  • Patients with a history of H2 receptor blocker use, proton pump inhibitor use or other GERD specific therapy within 30 days of surgery.
  • Any patient identified by their surgical care team as having a history of PONV warranting additional perioperative prophylaxis.
  • Known r suspected malignancy
  • Lactose intolerance

Recruiting US locations

  • Naval Medical Center Portsmouth

    Portsmouth, VA 23708

    Site contact: Casey Timmerman, DO · 757-953-7767 · casey.j.timmerman2.mil@health.mil

Study contacts (from the official record)

  • Casey Timmerman, DO · 757-953-7767 · casey.j.timmerman2.mil@health.mil
  • Melissa Infosino, MD · Melissa.R.Infosino.mil@health.mil
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Preoperative Use of Pantoprazole for Prevention of Post Operative… (NCT06488001) | Bored Studies