Preparedness Through Respiratory Virus Epidemiology and Community Engagement

Community Testing Component

Inclusion

• All community members are able to participate in the community testing component.

Exclusion

• There is no exclusion criteria and participants will not be excluded based on pregnancy status or age.

For Component A

Inclusion

• All ages
• AND Lives in service area of a recruitment center (i.e., within range of courier pick up)
• AND Plans to remain living in a recruitment area for the next 2 years.

Exclusion

• Inability to communicate in a language in which consent forms, materials, etc. are available
• OR Incarcerated
• OR Living in a congregate setting (e.g., assisted living, nursing home, university dormitories with shared bathroom and communal eating facilities)
• OR Unable/unwilling to participate in planned data and specimen collections
• OR Unable to comply with study procedures, as determined by study investigators
• OR Participation in clinical trials of investigational agents for respiratory viral infections during the three months prior to enrollment and for the duration of the study.

For Component B

Inclusion

Index case

• Detection of priority respiratory pathogen via laboratory or point-of-care test on the day of eligibility screening or in the previous 5 days, AND
• Lives in service area of a recruitment center (i.e., within range of courier pick up), AND
• Lives in a household with ≥1 other person and plans to remain in the household for at least the duration of specimen collection (i.e., 14 days), AND
• Has not been hospitalized since the date of symptom onset.

Household contacts

• Routinely sleep in the same household as index case and slept in household ≥1 night in the 7 days before index case symptom onset, AND
• Plan to remain in the household for at least the duration of specimen collection (i.e., 14 days).

Household

• There is ≥1 non-ill household member (i.e., asymptomatic and has not tested positive for the virus of the index case) on the day of eligibility screening or in the previous 5 days,
• AND all symptomatic persons in the household had a symptom or diagnosis onset date on the day of eligibility screening or in the previous 5 days.

Exclusion

Index case

• Lives in a congregate setting (e.g., assisted living, nursing home, university dormitories with shared bathroom and communal eating facilities)
• Meet any A1 exclusion criteria

Household contacts

• Has been hospitalized any time since date of primary case symptom onset
• Meets any A1 exclusion criteria

Household

• The enrollment visit occurs >6 days after the first symptom onset of primary case
• The primary case in the household is not enrolled
• The primary case has been hospitalized any time after the date of symptom onset