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RecruitingAccepts healthy volunteersPhase 4

Progesterone Preeclampsia

Medical University of South Carolina · NCT07448597

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · Women only
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
642
US sites recruiting
1
Study start
August 13, 2026
Record last updated
August 17, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This randomized controlled trial evaluates whether nightly vaginal micronized progesterone (400 mg) initiated before 12 weeks' gestation reduces the incidence of preeclampsia in low-risk pregnant individuals. Participants will be randomly assigned (1:1) to receive either vaginal progesterone through 16 weeks' gestation or routine prenatal care without progesterone. Maternal and neonatal outcomes-including development of preeclampsia, obstetric complications, gestational diabetes, preterm birth, and neonatal morbidity-will be collected via chart review. The study aims to determine whether early progesterone supplementation decreases the risk of preeclampsia.

Being studied: Progesterone supplementation

Conditions: Preeclampsia; Hypertensive Disorder of Pregnancy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Pregnant individuals receiving prenatal care at participating clinics
  • \<12 weeks gestation with a viable intrauterine pregnancy
  • Age ≥18 years
  • English-speaking

Exclusion Criteria

  • Unable or unwilling to self-administer vaginal progesterone
  • Inability or unwillingness to provide informed consent

Recruiting US locations

  • Medical University of South Carolina

    Charleston, SC 29401

    Site contact: Lauren Yacobucci, MD · 7163415115 · yacobucc@musc.edu

All pregnancy studies in South Carolina →
Progesterone Preeclampsia (NCT07448597) | Bored Studies