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Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry

Midwest Biomedical Research · with Kansas City Veteran Affairs Medical Center · NCT00574327

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
3000
US sites recruiting
1
Study start
January 2006
Record last updated
March 16, 2023

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to determine or evaluate the risk factors such as smoking, family history etc. that cause esophageal cancer and to determine the genetic changes that lead to esophageal cancer. The investigators hypothesis is that systematic collection of data on the natural history of GERD and BE patients and risk factors for development of BE in patients with chronic GERD and progression of BE to dysplasia and adenocarcinoma will provide useful information to develop a decision model for risk stratification and risk reduction strategies in these patients.

As of March 17, 2011, 585 patients have consented at the Kansas City VA Medical Center.

Conditions: Barrett's Esophagus; Gastroesophageal Reflux Disease; Esophageal Adenocarcinoma

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

All patients must be eligible for care that the Kansas City VA Hospital where this study was approved for enrollment.

Inclusion Criteria

  • Kansas City VA Patients with confirmed BE with and without dysplasia and patients with reflux disease (patients/cases); patients with other indicators for endoscopy such as anemia, weight loss, diarrhea, but without GERD and PE (controls).

Exclusion Criteria

  • Patients with uncontrolled significant comorbidities such as cardiovascular, pulmonary, renal, hepatic or metabolic diseases.
  • Presence of anticoagulation that would increase risk from biopsies
  • Patients unable to provide history
  • Patients with dyspepsia

Recruiting US locations

  • Department of Veterans Affairs Medical Center

    Kansas City, MO 64128

    Site contact: Prateek Sharma, MD

Study contacts (from the official record)

  • April D Higbee, RN, BSN · 816-861-4700 · april.higbee@va.gov
  • Carly Campbell, MS · 816-861-4700 · Carlissa.Campbell@va.gov
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Progression of Gastroesophageal Reflux Disease and Barrett's… (NCT00574327) | Bored Studies