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Project for Multi-Omics-Based Early Detection of Hepatocellular Carcinoma (PROMETHEA Study)

City of Hope Medical Center · NCT07265271

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
600
US sites recruiting
1
Study start
January 15, 2025
Record last updated
July 1, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, and early detection is critical for improving patient outcomes. Despite this, reliable non-invasive biomarkers for early-stage HCC are limited.

This study seeks to develop a multi-omics-based liquid biopsy assay, especially focusing on ncRNAs (e.g. tsRNA, miRNA, circRNA, lncRNA, etc.) for accurate detection of early-stage HCC.

Being studied: Small RNA sequence; Rt-qPCR; Rt-qPCR

Conditions: Hepatocellular Carcinoma (HCC)

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adults aged 18 to 100 years.
  • A histologically confirmed diagnosis of hepatocellular carcinoma.
  • A clinically diagnosed as chronic liver disease, including chronic hepatitis or liver cirrhosis, without evidence of hepatocellular carcinoma.
  • Healthy volunteers without known liver disease or malignancy.
  • Received standard diagnostic and staging procedures as per local guidelines
  • Availability of blood or other biospecimens.
  • Ability to provide written informed consent.

Exclusion Criteria

  • Lack of or inability to provide informed consent
  • History of other active malignancies within the past 5 years
  • Previous liver transplantation
  • Severe systemic infection or inflammatory disease at the time of enrollment
  • Inadequate sample quality or quantity

Recruiting US locations

  • City of Hope Medical Center

    Duarte, CA 91016

    Site contact: Ajay Goel, PhD · 626-218-3452 · ajgoel@coh.org

Study contacts (from the official record)

  • Goel Ajay, PhD · 626-218-3452 · ajgoel@coh.org
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Project for Multi-Omics-Based Early Detection of Hepatocellular… (NCT07265271) | Bored Studies