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Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)

Petter Bjornstad · with National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Seattle Children's Hospital · NCT05008276

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 8–14 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
100
US sites recruiting
2
Study start
September 27, 2021
Record last updated
March 24, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death. Youth-onset T2D typically manifests during or shortly after puberty in adolescents with obesity. Epidemiological data implicate puberty as an accelerator of kidney disease in youth with obesity and diabetes and the investigators posit that the link between puberty and T2D-onset may explain the high burden of DKD in youth-onset T2D. A better understanding of the impact of puberty on kidney health is needed to promote preservation of native kidney function, especially in youth with T2D.

Being studied: Aminohippurate Sodium Inj 20%; Iohexol Inj 300 MG/ML; Dextran 40

Conditions: Type 2 Diabetes Mellitus; Diabetic Kidney Disease; Adolescent Obesity; Pre Diabetes; Kidney Hypoxia; Puberty

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • HbA1c ≥6.0% for untreated high-risk group
  • BMI ≥ 85th %ile for high-risk group
  • Normal HbA1c ≤5.6% for control group
  • Type 1 diabetes (T1D) Antibody negative

Exclusion Criteria

  • History of Chronic kidney disease (CKD) or acute kidney injury (AKI)
  • Metabolic disorder prohibiting safe fasting
  • Iodine or penicillin allergy
  • Pregnancy
  • Thrombophilia
  • MRI contraindications
  • Hormone therapy

Recruiting US locations

  • Children's Hospital Colorado

    Aurora, CO 80045

    Site contact: Megan Kelsey, MD, MS · 720-777-0991 · Megan.Kelsey@childrenscolorado.org

  • Seattle Children's Hospital

    Seattle, WA 98102

    Site contact: Petter M Bjornstad, MD · (206) 616 3543 · pettermb@uw.edu

Study contacts (from the official record)

  • Petter Bjornstad, MD · (206) 616 3543 · pettermb@uw.edu
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Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress… (NCT05008276) | Bored Studies