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Rate of Total Joint Infection 90-day After Surgery Following Irrigation With Next Science No-Rinse Solution vs SOC Alone

Northwell Health · with Next Science TM · NCT05519007

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Any age listed · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
936
US sites recruiting
3
Study start
September 26, 2023
Record last updated
May 23, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

A prospective, single-site, double-arm, parallel, interventional, randomized, controlled clinical trial to assess 90-day rate of joint infections in subjects undergoing primary hip replacements after administration of Next Science No-Rinse Solution (hereby referred to as NS) vs SOC (saline irrigation). The Next Science treatment arm will exhibit greater reduction in rate of 90-day post-operative joint infection than SOC (saline) arm

Being studied: No-Rinse Solution (NS); Saline irrigation

Conditions: Joint Infection

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adult that meets at least one of the below criteria at time of screening:
  • American Society of Anesthesiologists (ASA) 3 2
  • BMI >35
  • Patient with functional limitations as a result of disease1:
  • Poorly treated hypertension
  • Poorly treated diabetes
  • Chronic renal failure
  • Bronchospastic disease
  • Disease with intermittent exacerbations
  • Stable angina
  • Implanted pacemaker
  • Known history as an active nicotine use (smoker)
  • Known history of uncontrolled diabetes mellitus (HgbA1C > 7.0)
  • Known history of end stage organ disease
  • Known history of inflammatory arthritis and currently on rheumatological medication (DMARDs)
  • Known history of current active cancer treatment (chemotherapy)
  • Venous Disease (Surgical Risk Calculator from ACS-NSQIP)
  • Charleston Comorbidity Score > 2
  • Elixhauser Score >11
  • Age 65 or older
  • Subject is scheduled to primary joint replacement.
  • Subject is willing and able to comply with all study procedures including transportation to the study site for all scheduled visits and be available for the duration of the study.
  • Subject has understood, signed, and dated the informed consent form.

Exclusion Criteria

  • Unable to provide signed and dated informed consent.
  • Unable or unwilling to comply with all study-related procedures.
  • Known history of allergic reaction to any of the study products or its components, including any products used for standard of care (such as dressings or any coverings)
  • Subject has contraindications to general anesthesia
  • Any subject positive for Covid-19 virus at time of surgical screening
  • Subjects have evidence of prolonged QT segment, per EKG.
  • Subjects from a vulnerable population, in accordance with 45 CFR 46 Subparts B, C, and D

Recruiting US locations

  • North Shore University Hospital

    Manhasset, NY 11030

    Site contact: Meriton Ruhani

  • Long Island Jewish Medical Center

    New Hyde Park, NY 11040

    Site contact: Meriton Ruhani

  • Lenox Hill Hospital

    New York, NY 10075

    Site contact: Meriton Ruhani · mruhani@northwell.edu

Study contacts (from the official record)

  • Meriton Ruhani · (212)434-4724 · ruhanimeriton@gmail.com
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Rate of Total Joint Infection 90-day After Surgery Following… (NCT05519007) | Bored Studies