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Resting State Changes Following Theta Burst Stimulation

Nicholas Balderston, PhD · NCT05322239

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–60 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
200
US sites recruiting
1
Study start
November 17, 2022
Record last updated
January 7, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Transcranial magnetic stimulation (TMS) is increasingly being applied to effectively treat mental illness, however efforts to quantify the effects of TMS on the network architecture of the brain have largely been limited in scope and tied to specific neurologic and psychiatric disorders. The objective of the current work is to build and validate a whole-brain, domain-general model of brain connectivity changes following TMS, based on physical models of the current distribution at the cortex. PUBLIC HEALTH RELEVANCE: This work is relevant to public health because it will provide direct evidence that brain connectivity changes following neuromodulatory TMS vary as a function of the current density at the cortex, which can be used to predict psychiatric symptom change following neuromodulatory TMS.

Being studied: Intermittent Theta Burst Stimulation; Continuous Theta Burst Stimulation

Conditions: Brain Connectivity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Able to give their consent
  • Right-handed

Exclusion Criteria

  • Non-english speaking
  • Any significant medical problems
  • Current or past Axis I psychiatric disorder(s),
  • Active or history of active suicidal ideation
  • Alcohol/drug problems in the past year or lifetime alcohol or drug dependence
  • Medications that act on the central nervous system
  • History of seizure
  • History of epilepsy or other neurological problems
  • Increased risk of seizure for any reason
  • Pregnancy
  • Any medical condition that increases risk for fMRI or TMS
  • Any metal in their body which would make having an MRI scan unsafe
  • Any sort of medical implants
  • Claustrophobia

Recruiting US locations

  • University of Pennsylvania

    Philadelphia, PA 19104

    Site contact: Nicholas l Balderston, PhD · 215-746-3058 · nicholas.balderston@pennmedicine.upenn.edu

Study contacts (from the official record)

  • Nicholas L Balderston · 2157463058 · nicholas.balderston@pennmedicine.upenn.edu
All healthy volunteers studies in Pennsylvania →
Resting State Changes Following Theta Burst Stimulation (NCT05322239) | Bored Studies