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RecruitingAccepts healthy volunteersEarly Phase 1

Restructuring the Alpha-Gamma Code in Aging Vision

Boston University Charles River Campus · NCT07208318

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
240
US sites recruiting
1
Study start
April 2, 2026
Record last updated
July 16, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Tests whether age-related visual deficits arise from disrupted alpha-gamma coupling in visual cortex (V1) and MT. Uses fMRI, source-resolved HD-EEG, and personalized complex-waveform HD-tACS to (1) quantify aging effects on phase-amplitude coupling, (2) drive PAC into a preferred "gamma-at-alpha-troughs" state, and (3) bidirectionally change perception by aligning gamma to alpha troughs vs peaks. Two five-day, double-blind, sham-controlled studies (n=120 each) target contrast sensitivity (V1) and 3D shape-from-motion (MT), aiming for mechanistic insight and remediation in older adults with implications for ADRD.

Being studied: High definition transcranial electrical current stimulation

Conditions: Aging; Visual Perception; Noninvasive Brain Stimulation

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 18+ years of age or older
  • normal or corrected-to-normal visual acuity, color vision, and stereo vision

Exclusion Criteria

  • not pregnant,
  • no metal implants in head,
  • no implanted electronic devices,
  • no history of neurological problems or head injury,
  • no skin sensitivity,
  • no claustrophobia,
  • no dementia (normal Mini Mental State Examination between 24-30; Montreal Cognitive Assessment > 25)
  • no depression (normal Beck Depression Inventory II \<13; Geriatric Depression Scale \< 10)
  • no ophthalmological diseases (e.g., strabismus, glaucoma, cataract, macular degeneration)
  • no history of psychosis
  • no cognitive deficits (MMSE score>24; MoCA>25)
  • cannot be taking any psychoactive medication.

Recruiting US locations

  • 111 Cummington Mall, Boston University

    Boston, MA 02215

    Site contact: Robert Reinhart, PhD · 617-353-9481 · rmgr@bu.edu

Study contacts (from the official record)

  • Robert Reinhart, PhD · (617) 353-9481 · rmgr@bu.edu
All healthy volunteers studies in Massachusetts →
Restructuring the Alpha-Gamma Code in Aging Vision (NCT07208318) | Bored Studies