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Retinal Imaging in Neurodegenerative Disease

Duke University · with University of Edinburgh in Scotland, Tan Tock Seng Hospital in Singapore · NCT03233646

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
2000
US sites recruiting
1
Study start
July 20, 2017
Record last updated
February 4, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.

Being studied: Retinal and Choroidal Imaging

Conditions: Alzheimer's Disease; Mild Cognitive Impairment; Parkinson's Disease; Multiple Sclerosis; Huntington Disease; Lewy Body Dementia; Frontotemporal Dementia; Amyotrophic Lateral Sclerosis (ALS); APOE-4 Positive; Traumatic Brain Injury; Concussion; Post-Traumatic Stress Disorder; Down Syndrome; Neuro-Degenerative Disease; Normal Cognition

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adults with neurodegenerative disease ((MCI, PD, AD, FTD, DLB, ALS, MS, HD, TBI, concussion, PTSD and other neurodegenerations as well as Down Syndrome)
  • Adults without neurodegenerative disease

Exclusion Criteria

  • Inability to cooperate with or complete testing or other neurologic or age- related ocular conditions that would impact image acquisition.
  • Eyes that have had intraocular surgery, other than cataract surgery.

If two eyes satisfy the inclusion criteria, both eyes will be included in the study. If one eye satisfies the inclusion criteria, the eye that qualifies will be included in the study.

Recruiting US locations

  • Duke University Medical Center

    Durham, NC 27705

    Site contact: Sharon Fekrat, MD FACS FASRS · 919-681-3937 · imind@duke.edu

Study contacts (from the official record)

  • Sharon Fekrat, MD FACS FASRS · 919-681-3937 · imind@duke.edu
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Retinal Imaging in Neurodegenerative Disease (NCT03233646) | Bored Studies