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RecruitingAccepts healthy volunteersEarly Phase 1

Reversing Glucose and Lipid-mediated Vascular Dysfunction

University of Kansas Medical Center · NCT04832009

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–79 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
46
US sites recruiting
1
Study start
May 9, 2022
Record last updated
June 5, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of our study is to understand the extent to which the blood vessels are affected by glucose and fat (lipids) in lean healthy adults and if these changes in the blood vessels contribute to the development of high blood pressure.

Being studied: Dextrose 20 % in 500 ML Injection; Intralipid; Saline; Ascorbic acid

Conditions: Blood Pressure; Hypertension

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Lean: BMI \< 25 kg/m
  • Normal insulin sensitivity: (calculation based on fasting glucose and insulin concentrations in blood)
  • Middle-aged: 18-79 years
  • Blood pressure: \< 140 (systolic) and \< 90 mmHg (diastolic
  • Weight stable (+/- 5 lbs) for the previous 3 months
  • Participants must be willing and able to discontinue taking any vitamin C or E supplements or omega-3 fatty acids beginning 2 weeks prior.
  • Able and willing to provide written informed consent

Exclusion Criteria

  • Diabetes mellitus Type I or Type II: fasting glucose \< 126 mg/dL and/or HbA1c \< 6.5%
  • Current smoker or History of smoking in the past 3 months.
  • Hyperlipidemia: Fasting triglycerides \< 250 mg/dL
  • Hypertension: >130/80 mmHg
  • History of heart disease (e.g., myocardial infarction, stent, heart attack, stroke, heart failure, valvular heart disease, cardiomyopathy)
  • History of vascular disease (e.g., bypass, stroke)

Recruiting US locations

  • University of Kansas Medical Center

    Kansas City, KS 66103

    Site contact: Seth W. W Holwerda · 9729223230 · sholwerda@kumc.edu

Study contacts (from the official record)

  • Seth W Holwerda, PhD · 9729223230 · sholwerda@kumc.edu
  • Davina A Clonch · 9132266009 · shoggirl@gmail.com
All heart & blood pressure studies in Kansas →
Reversing Glucose and Lipid-mediated Vascular Dysfunction (NCT04832009) | Bored Studies