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Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes

University of Colorado, Denver · with University of Virginia, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NCT04791371

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 30–55 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
150
US sites recruiting
2
Study start
June 17, 2022
Record last updated
March 23, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance.

Being studied: Cardiovascular exercise

Conditions: Type 2 Diabetes; Overweight and Obesity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Sedentary (defined as less than 1 hour per week of physical activity)
  • BMI: 25-40
  • Men and women with and without type 2 diabetes

Exclusion Criteria

  • Documented cardiovascular disease
  • Uncontrolled hypertension: disease systolic blood pressure (SBP) > 150, diastolic blood pressure (DBP)> 110
  • Obstructive pulmonary disease or asthma
  • Peripheral neuropathy
  • Physical impairment that would limit exercise ability
  • Subjects taking beta blockers, calcium channel blockers, insulin, or Thiazolidinediones (TZD)
  • Current or past smoking within the last 1 years
  • Current tobacco use
  • Anemia
  • Control HbA1c > 5.7, T2DM HbA1c > 9
  • Pregnant, nursing or hormonal therapy (other than contraceptives)
  • Peri or post-menopausal women
  • Type 1 diabetes
  • Hepatic or renal disease.

Recruiting US locations

  • University of Colorado

    Aurora, CO 80045

    Site contact: Benjamin Juckett, MS · 303-724-1338 · benjamin.juckett@cuanschutz.edu

  • University of Virginia

    Charlottesville, VA 22908

    Site contact: Lee Hartline, MEd · 434-924-5247 · lmh9d@virginia.edu

Study contacts (from the official record)

  • Benjamin Juckett, MS · 303-724-1338 · benjamin.juckett@cuanschutz.edu
All weight loss studies in Colorado →
Role of Microvascular Insulin Resistance and Cardiorespiratory… (NCT04791371) | Bored Studies