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Role of the Gut Microbiome in Complex Regional Pain Syndrome

Washington University School of Medicine · NCT03612193

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
140
US sites recruiting
1
Study start
December 19, 2018
Record last updated
November 5, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The objective of this prospective, observational study is to determine the association between the composition of the gut microbiota and the severity and persistence of Complex Regional Pain Syndrome symptoms (Study A). The objective of Study B, a longitudinal study of microbiota biomarkers of patients with newly diagnosed CRPS is to determine if the researchers can predict which patients are more likely to recover compared to those who do not. A secondary objective of both studies is to examine cognitive flexibility in relation to outcomes (study A and B).

Conditions: Complex Regional Pain Syndromes

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Study A: Cross-sectional study

Inclusion criteria, cases:

  • Adults over the age of 18
  • Current (\< 1 year duration) or former (> 1 year) diagnosis of Complex Regional Pain Syndrome by the Budapest criteria
  • English as primary language
  • able to consent

Inclusion criteria, controls

  • Adults over age of 18
  • Cohabitant of person with current or former diagnosis of CRPS

Study B: Longitudinal Study

Inclusion criteria, cases:

  • Adults over the age of 18
  • Recent diagnosis (\<6 months) of Complex Regional Pain Syndrome by the Budapest criteria
  • English as primary language
  • able to consent

Inclusion criteria, controls

  • Adults over age of 18
  • Cohabitant of person with diagnosis of CRPS

Study A and B: Exclusion criteria, cases and controls:

  • Unwilling to participate in the study
  • Lives alone
  • Current use of probiotics and unwilling to stop for 1 week prior to stool sample
  • Pregnant or lactating
  • Vegan diet

Recruiting US locations

  • Washington University School of Medicine

    St Louis, MO 63110

    Site contact: Laura Crock, MD

Study contacts (from the official record)

  • Lara Crock, MD PhD · 314-546-3882 · crockl@wustl.edu
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Role of the Gut Microbiome in Complex Regional Pain Syndrome (NCT03612193) | Bored Studies