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Role of Transposable Elements in Septic Immune Aging

University of California, San Francisco · with National Cancer Institute (NCI) · NCT06809868

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
116
US sites recruiting
1
Study start
February 14, 2025
Record last updated
January 30, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is:

  • Do transposable elements prematurely age the immune systems of patients with sepsis?
  • Do transposable elements correlate with increased mortality in patients with sepsis in the ICU?
  • Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU?

Participants will have blood drawn from them but will not be subjected to additional interventions.

Being studied: RNA and DNA Sequencing

Conditions: Sepsis; Sepsis and Septic Shock; Sepsis With Multiple Organ Dysfunction (MOD); Sepsis With Acute Organ Dysfunction; Sepsis, Severe; Sepsis at Intensive Care Unit; Sepsis, Severe Sepsis and Septic Shock; Sepsis, Septic Shock

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age 18 or older
  • Admitted to ICU with sepsis (Sepsis 3 Criteria)
  • SOFA score of at least 2 at time of enrollment

Exclusion Criteria

  • Patients on organ transplantation immunosuppression
  • Patients with preexisting leukopenia
  • Cancer patients receiving CAR-T therapy
  • Patients who are under 18 years of age or otherwise deemed pediatric
  • Patients with an ongoing bleeding diathesis (ie: DIC, hemorrhagic shock)
  • Patients with a chronic hemoglobin below 7.0
  • Patients who, prior to their ICU admission, are blood transfusion dependent

Recruiting US locations

  • University of California, San Francisco

    San Francisco, CA 94143

    Site contact: Alexendar R Perez, M.D., Ph.D · 415-476-1000 · Alexendar.Perez@ucsf.edu

Study contacts (from the official record)

  • Alexendar R Perez, M.D., Ph.D · 415-476-1000 · Alexendar.Perez@ucsf.edu
  • Matthieu Legrand, M.D., Ph.D · 415-476-1000 · matthieu.legrand@ucsf.edu
All healthy volunteers studies in California →
Role of Transposable Elements in Septic Immune Aging (NCT06809868) | Bored Studies