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Routine Validation and Reproducibility Testing of Laboratory Measures and Research Techniques Used for Metabolism Research (VAL)

Bettina Mittendorfer · NCT06286761

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–75 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
100
US sites recruiting
1
Study start
May 8, 2024
Record last updated
August 4, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research on chronic diseases (obesity, pre-diabetes and type-2 diabetes, dyslipidemia, non-alcoholic fatty liver disease, cardiovascular disease, etc.), nutrition, and metabolism (the process by which a substance is handled in your body) at the University of Missouri. As technology changes and we start to use new testing methods, it is necessary to compare results from old tests, equipment and devices and new tests, equipment, or devices and the reproducibility of these measurements to make sure we are getting accurate results. Reproducibility means performing the same test more than once to see if the same results can be achieved each time.

Being studied: endothelial cell collection

Conditions: Obesity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • ≥18 and ≤75 years of age
  • body mass index ≥18.5 and ≤45 kg/m2
  • Weight stable (i.e., ≤3% change)
  • ≤150 min of structured exercise/week for at least 2 months before entering the study
  • Blood glucose: \< 126 mg/dl fasted, \< 200 mg/dl with 2 hour oral glucose tolerance testing
  • Hemoglobin A1C (HbA1C) ≤6.5%
  • Dyslipidemia triglycerides ≥125 mg/dL
  • No chronic kidney disease
  • Not vegan or vegetarian or on high protein diet (e.g. Atkins) or supplements that are not allowed
  • No intolerance or allergies to study diet ingredients
  • No excessive alcohol or tobacco consumption

Exclusion Criteria

  • \<18 and >75 years of age
  • body mass index \<18.5 or >45 kg/m2
  • history of or current significant organ system dysfunction (e.g., heart disease, stroke, diabetes, cancer in remission for \<5 years, dementia, chronic kidney disease)
  • allergies or intolerances to meal ingredients, vegans or vegetarians
  • use of medications that could confound the study outcomes (e.g., anti-inflammatories, immune modulators, etc)
  • take dietary supplements (e.g., certain pre- and pro-biotics, fiber, fish oil supplements)
  • engaged in regular structured exercise >150 min per week
  • alcohol use disorder as defined by the National Institute of Alcohol Abuse and Alcoholism or use of controlled substances
  • pregnant women
  • persons who use tobacco
  • prisoners
  • the inability to grant voluntary informed consent.

Recruiting US locations

  • University of Missouri School of Medicine

    Columbia, MO 65212

    Site contact: Vasavi Shabrish · v.shabrish@missouri.edu

Study contacts (from the official record)

  • Heather McHatton, MPH, RN · (573) 882-7619 · heathermchatton@health.missouri.edu
  • Vasavi Shabrish, PhD · v.shabrish@missouri.edu
All weight loss studies in Missouri →
Routine Validation and Reproducibility Testing of Laboratory… (NCT06286761) | Bored Studies