Skip to content
Bored Studies
RecruitingAccepts healthy volunteers

Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis

Massachusetts General Hospital · with Cystic Fibrosis Foundation · NCT06216704

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 13–20 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
36
US sites recruiting
1
Study start
April 1, 2024
Record last updated
October 30, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The investigators will be evaluating bone marrow composition via magnetic resonance imaging in adolescents diagnosed with cystic fibrosis (CF) compared to healthy, matched controls. The investigators will also be assessing their bone mineral density via other imaging modalities, including dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT). This longitudinal project will focus on abnormalities in bone marrow composition, and specifically whether adolescents with diagnosed with CF exhibit increased bone marrow fat, its association with bone mineral density (BMD) and the underlying pathophysiology, including glycemic control, inflammation, and bone turnover markers.

Being studied: Magnetic resonance relaxometry; Magnetic resonance spectroscopy; Blood Draw; DXA; pQCT

Conditions: Cystic Fibrosis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 13-20 years old
  • Cystic fibrosis with pancreatic insufficiency
  • Must have a stable treatment regimen, including CFTR modulator usage unchanged for the prior three months
  • Liver transplant recipients will be eligible, as long as they are at least 1 year post-transplant and are no longer on Prednisone for immunosuppressive therapy

Exclusion Criteria

  • Diagnosis of other chronic disease affecting bone health
  • Active use (within the past 3 months) of medications that are known to affect skeletal metabolism
  • CF exacerbation or glucocorticoid exposure within the prior 1 month
  • Lung transplant

Recruiting US locations

  • Boston Children's Hospital

    Boston, MA 02115

    Site contact: Rebecca Gordon, MD · rebecca.gordon@childrens.harvard.edu

Study contacts (from the official record)

  • Rebecca Gordon, MD · (617) 355-7476 · rebecca.gordon@childrens.harvard.edu
All healthy volunteers studies in Massachusetts →
Skeletal Health and Bone Marrow Composition in Adolescents With… (NCT06216704) | Bored Studies