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Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease

Massachusetts General Hospital · NCT04508088

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 13–20 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
92
US sites recruiting
1
Study start
September 10, 2020
Record last updated
October 30, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls. The investigators will also be assessing their bone mineral density via other imaging modalities, including dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. This longitudinal project will focus on abnormalities in bone marrow composition, and specifically whether adolescents with newly diagnosed CD exhibit increased bone marrow fat, its association with bone mineral density (BMD) and the underlying pathophysiology, including bone turnover markers and immune cellular/molecular parameters.

Being studied: Coronal T1 weighted spin echo images; Spin-lattice relaxation (T1); Magnetic resonance spectroscopy; Blood Draw

Conditions: Inflammatory Bowel Disease; Crohn Disease

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Crohn's Disease diagnosed within the past 3 months, or a healthy, matched control

Exclusion Criteria

  • Participants with chronic disease known to affect skeletal metabolism
  • Participants on certain medications within the prior 3 months that are known to affect skeletal metabolism
  • Participants who are pregnant
  • Participants who have a history of: claustrophobia, internal body metal that is not compatible with MRI machine, or a known abnormality on or adjacent to the left knee

Recruiting US locations

  • Boston Children's Hospital

    Boston, MA 02115

    Site contact: Rebecca Gordon, MD

Study contacts (from the official record)

  • Rebecca Gordon, MD · (617) 355-7476 · rebecca.gordon@childrens.harvard.edu
All healthy volunteers studies in Massachusetts →
Skeletal Health and Bone Marrow Composition in Newly Diagnosed… (NCT04508088) | Bored Studies