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RecruitingAccepts healthy volunteersPhase 4

Sleep Apnea in Elderly

VA Office of Research and Development · NCT02703220

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 60–89 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
100
US sites recruiting
1
Study start
July 3, 2015
Record last updated
August 21, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Sleep-disordered breathing (SDB or sleep apnea) is very common among elderly Veterans and leads to increased morbidity and mortality in this population. The proposal aims to identity whether oxygen, finasteride and acetazolamide can be effective in reducing unstable breathing and eliminating sleep apnea in the elderly via different mechanisms. This proposal will enhance the investigators' understanding of the pathways that contribute to the development of sleep apnea in the elderly. The investigators expect that the results obtained from this study will positively impact the health of Veterans by identifying new treatment modalities for sleep apnea. A cumulative effect of the investigators' research will fulfill the long-term goal of improving the quality of life of elderly Veterans suffering from sleep apnea and its potential life-threatening complications.

Being studied: Hyperoxia/oxygen; Acetazolamide; Finasteride

Conditions: Sleep Apnea; Elderly Adults

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adults with mild to moderate sleep apnea with Apnea-Hypopnea Index (AHI)>/=5 to 20/hour with central, obstructive, mixed apneas and hypopneas
  • For the finasteride protocol elderly men with above criteria will be enrolled

Exclusion Criteria

  • Patients with severe sleep apnea (Apnea-Hypopnea Index (AHI)>20/hour)
  • Patients with history of prostate cancer
  • Males with hypogonadism
  • History of cardiac disease, including myocardial infarction
  • Bypass surgery
  • Atrial and ventricular tachy-bradycardias
  • Systolic congestive heart failure and Cheyne-Stokes respiration
  • Current unstable angina
  • Stroke
  • Schizophrenia
  • Untreated hypothyroidism
  • Seizure disorder
  • Preexisting renal failure and liver disorders
  • Failure to give informed consent.
  • Patients with significant pulmonary diseases by history and abnormal pulmonary function testing, including moderate obstructive/restrictive lung/chest wall disorders with resting oxygen saturation of \<96% or on supplemental oxygen
  • Patients on certain medications including:
  • study drugs
  • sympathomimetics/parasympathomimetics or their respective blockers
  • narcotics
  • antidepressants
  • anti-psychotic agents
  • other central nervous system (CNS) altering medications
  • current alcohol, tobacco or recreational drug use
  • Patients with Body mass index (BMI)>34 kilograms per square meter (kg/m2) will be excluded to avoid the effects of morbid obesity on pulmonary mechanics and ventilatory control
  • Elderly with unstable gait or mobility issues that may preclude safe participation
  • Individuals with allergy to finasteride or acetazolamide will be excluded from the specific protocol
  • Pregnant women

Recruiting US locations

  • John D. Dingell VA Medical Center, Detroit, MI

    Detroit, MI 48201-1916

    Site contact: Lynn M Huber · (313) 576-3106 · lynn.huber@va.gov

Study contacts (from the official record)

  • Ruchi Rastogi, MS · (313) 576-4464 · ruchi.rastogi@va.gov
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Sleep Apnea in Elderly (NCT02703220) | Bored Studies